71321-16-9Relevant articles and documents
Total synthesis of (+)-crocacin A
Chakraborty, Tushar K.,Laxman, Pasunoori
, p. 4989 - 4992 (2007/10/03)
Total synthesis of the potent antifungal and cytotoxic agent (+)-crocacin A is described. The crucial (Z)-5,6-enoic amide moiety in this molecule was built by stereoselective partial reduction of a skipped diyne precursor. The diene, thus obtained, was transformed into a silyl epoxide that was regioselectively opened with an azide ion to furnish an α-azido-β-hydroxyalkylsilane intermediate. Peterson elimination of this β-hydroxysilane component in the final step resulted in the formation of the (Z)-8,9-enamide moiety of the molecule leading to a successful completion of its total synthesis.
Concise synthesis of optically active ring-A substituted tryptophans
Ma, Chunrong,Liu, Xiaoxiang,Yu, Shu,Zhao, Shuo,Cook, James M.
, p. 657 - 660 (2007/10/03)
A concise synthesis of optically active tryptophan derivatives was developed via diastereoselective alkylation of the Schollkopf chiral auxiliary 4 to provide alkyne 2 which underwent palladium-catalyzed heteroannulation with iodoanilines 1 to furnish protected tryptophans 3. Hydrolysis and subsequent saponification of 3 provided the desired tryptophans 12 in good yields.
Preparation of 2-iodo-1,3-butadienes from 1-trimethylsilyl-2,3- butadienes and their functionalizations
Nishiyama, Takashi,Esumi, Tomoyuki,Iwabuchi, Yoshiharu,Irie, Hiroshi,Hatakeyama, Susumi
, p. 43 - 46 (2007/10/03)
Successive treatment of 1-trimethylsilyl-2.3-butadienes with iodine and tetra-n-butylammonium fluoride in the same flask affords 2-iodo-1.3- butadienes in good yields and their palladium-catalyzed carbonylation and alkynylation allows introduction of este
