71280-22-3

Basic information

• Product Name: toluene-4-sulfonic acid 4-(2-methyl-[1,3]dioxolan-2-yl)-butyl ester
• Synonyms: toluene-4-sulfonic acid 4-(2-methyl-[1,3]dioxolan-2-yl)-butyl ester
• CAS NO: 71280-22-3
• Molecular Weight: 314.403
• Mol File: 71280-22-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: toluene-4-sulfonic acid 4-(2-methyl-[1,3]dioxolan-2-yl)-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: toluene-4-sulfonic acid 4-(2-methyl-[1,3]dioxolan-2-yl)-butyl ester(71280-22-3)
• EPA Substance Registry System: toluene-4-sulfonic acid 4-(2-methyl-[1,3]dioxolan-2-yl)-butyl ester(71280-22-3)

Safety Data

• Hazardous Substances Data: 71280-22-3(Hazardous Substances Data)

Upstream product

• 109-49-9 5-Hexen-2-one 
• 20449-21-2 2-(but-3-en-1-yl)-2-methyl-1,3-dioxolane 
• 5745-75-5 4-(2-methyl-[1,3]-dioxolan-2-yl)butan-1-ol 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 10226-54-7 7-(5-keto-hexyl)-1,3-dimethylxanthine 

Relevant articles and documents

Potentiation of cADPR-induced Ca2+-release by methylxanthine analogues

Caffeine and other methylxanthines are known to induce Ca2+-release from intracellular stores via the ryanodine receptor. In the present work, a range of caffeine analogues, in which methyl groups at the 1 and 7 positions were replaced with alkyl chains containing different functional groups (oxo, hydroxyl, propargyl, ester, and acids), were synthesized. These compounds were then screened for their ability to potentiate Ca2+-release induced by cADPR (an endogenous modulator of ryanodine receptors) in sea urchin egg homogenates. Two of the synthesized methylxanthines, 1,3-dimethyl-7-(7- hydroxyoctyl)xanthine (37) and 3-methyl-7-(7-oxooctyl)-1-propargylxanthine (66), were shown to be more potent than caffeine in potentiating cADPR- induced Ca2+-release, while 1,3-dimethyl-7-(5-ethylcarboxypentyl)xanthine (14) was shown to be more efficacious. The development of new methylxanthine analogues may lead to a better understanding of ryanodine receptor function and could possibly provide novel therapeutic agents.