71203-35-5 Usage
Description
ML 141 is a small molecule inhibitor that targets the CDC42 GTPase, a member of the Rho family of small GTPases. It is used in various applications, including as an actin regulator inhibitor and a selective, non-competitive inhibitor of Cdc42.
Uses
Used in Cell Biology Research:
ML 141 is used as an inhibitor of Rho kinase to study the role of small Rho GTPases on the localization of peripheral nuclei and as an actin regulator inhibitor to determine which actin regulators and nucleators are involved in the assembly of F-actin cages around damaged mitochondria.
Used in Pharmaceutical Research:
ML 141 is used as a selective, non-competitive inhibitor of Cdc42 to treat CCD-1070Sk cells. It has also been used to inhibit CDC42 GTPase in human immortalized gingival epithelial (HIGE) cells to study its potential therapeutic effects.
Biochem/physiol Actions
ML 141 is a potent, selective inhibitor of the Rho family GTPase cdc42. The IC50 for inhibition of enzymatic activity is 200 nM, with no activity against Rho family members Rac, Ras or Rab. Cdc42 has been implicated in the regulation of actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. This complex mediates the polymerization of actin into branched networks and regulates important functions including cell adhesion, cytoskeletal arrangement, phagocytosis and host-pathogen interactions, motility, migration, and membrane protein trafficking.
Check Digit Verification of cas no
The CAS Registry Mumber 71203-35-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,1,2,0 and 3 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 71203-35:
(7*7)+(6*1)+(5*2)+(4*0)+(3*3)+(2*3)+(1*5)=85
85 % 10 = 5
So 71203-35-5 is a valid CAS Registry Number.
71203-35-5Relevant articles and documents
Synthesis of sulfonamides bearing 1,3,5-triarylpyrazoline and 4-thiazolidinone moieties as novel antimicrobial agents
Thach, Thi-Dan,Le, Thi Tuong-Vi,Nguyen, Huu Thien-An,Dang, Chi-Hien,Dang, Van-Su,Nguyen, Thanh-Danh
, p. 158 - 162 (2020/05/08)
Two series of sulfonamides were synthesized from 4-hydrazinylben-zenesulfonamide as the key starting material. 1,3,5-Triarylpyrazoline sulfonamides (2a-i) were obtained by cyclocondensation of various chalcones in 53-64 % yields, while 4-thiazolidinone derivatives (4a-e) were synthesized by cyclocondensation between mercaptoacetic acid and different phenylhydrazones in 43-62 % yields. The synthesized compounds were characterized based on FTIR, 1H-NMR, 13C-NMR and HRMS data. The sulfonamides were evaluated for their in vitro antimicrobial activities against four bacterial strains (E. coli, P. aeruginosa, B. subtillis and S aureus), two filamentous fungal strains (A. Niger and F. oxysporum) and two yeast strains (C. albicans and S. cerevisiae). Seven pyrazolines, 2a-c and 2e-h, exhibited significant inhibition of different microbial strains. Among them, compound 2b displayed good antifungal activity against A. Niger (MIC value at 12.5 μg mL-1) over the reference drug.
Pyrazole Derivatives with Possible Hypoglycemic Activity
Faid-Allah, Hassan M.,Mokhtar, Hassan M.
, p. 245 - 249 (2007/10/02)
Condensation of p-sulphamylphenylhydrazine hydrochloride with different chalcones, leads either to hydrzones (2) or to pyrazolines (3) depending on the reaction conditions.The hydrazones (2) are readily converted into pyrazolines (3) on heating with hydro
