71-81-8 Usage
Description
Isopropamide Iodide is an anticholinergic compound that exhibits inhibitory activity. It functions as a muscarinic receptor antagonist, making it a potential candidate for the treatment of various cognitive disorders.
Uses
Used in Pharmaceutical Industry:
Isopropamide Iodide is used as a muscarinic receptor antagonist for the treatment of diseases affecting cognition, including Alzheimer's disease. Its inhibitory activity on muscarinic receptors helps in managing the symptoms associated with cognitive decline and improving the overall quality of life for patients suffering from such conditions.
Originator
Darbid,SKF,US,1957
Manufacturing Process
γ-Diisopropylamino-α,α-diphenylbutyronitrile (60 g) was added in several
portions to a mixture of sulfuric acid (150 ml) and water (15 ml) and the
solution was heated 3% hours on the steam bath and then poured on ice and
made basic with NH4OH. The γ-diisopropylamino-α,α-diphenylbutyramide
precipitated as a solid, which was taken up in methylene chloride from an
aqueous slurry. The methylene chloride was separated and dried by filtering
through anhydrous K2CO3. The solvent was removed by distillation, leaving
the amide which was crystallized from Skellysolve B five times and found then
to have MP 87.0° to 88.5°C.γ-Diisopropylamino-α,α-diphenylbutyramide in propanol was refluxed 4 hours
in the presence of excess methyl iodide. Upon dilution of the solution with
ethyl acetate (100 ml per 50 ml isopropyl alcohol) and cooling γ-
diisopropylamino-α,α-diphenylbutyramide methiodide precipitated, was
collected by filtration and recrystallized (9.0 g) by dissolving in a hot mixtureof 100 ml isopropyl alcohol and 10 ml methanol and then diluting with 90 ml
Skellysolve B, to give 8.3 g recrystallized product, MP 182° to 184°C.
Therapeutic Function
Spasmolytic
Clinical Use
ISOPROPAMIDE IODIDE is used as adjunctive therapy in the treatment of pepticulcer and other conditions of the GI tract associated withhypermotility and hyperacidity. It has the usual side effectsof anticholinergics (dryness of mouth, mydriasis, difficulturination) and is contraindicated in glaucoma, prostatic hypertrophy,etc.
Check Digit Verification of cas no
The CAS Registry Mumber 71-81-8 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 7 and 1 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 71-81:
(4*7)+(3*1)+(2*8)+(1*1)=48
48 % 10 = 8
So 71-81-8 is a valid CAS Registry Number.
InChI:InChI=1/C23H33N2O.HI/c1-18(2)25(5,19(3)4)17-16-23(22(24)26,20-12-8-6-9-13-20)21-14-10-7-11-15-21;/h6-15,18-19H,16-17H2,1-5H3,(H2,24,26);1H
