70318-34-2Relevant articles and documents
Designing, structural elucidation, comparison of DNA binding, cleavage, radical scavenging activity and anticancer activity of copper(I) complex with 5-dimethyl-2-phenyl-4-[(pyridin-2-ylmethylene)-amino]-1,2-dihydro-pyrazol-3-one Schiff base ligand
Sathiyaraj, Subbaiyan,Sampath, Krishnan,Butcher, Ray J.,Pallepogu, Raghavaiah,Jayabalakrishnan, Chinnasamy
, p. 81 - 89 (2013)
A novel copper(I) Schiff base complex has been synthesized and fully characterized by spectral, analytical and structural modes. Single crystal X-ray diffraction studies revealed that the copper(I) complex [CuCl(PPh 3)L] has a distorted tetrahedral geometry around the central copper(I) ion. The interaction of the ligand and the complex with CT-DNA has been explored by absorption titration method which revealed that the compounds could interact with CT-DNA through intercalation. A gel electrophoresis assay demonstrated the ability of the complex to cleave the pBR322 DNA. The antioxidative properties showed that the copper(I) complex has a strong radical-scavenging potency than ligands. Further the cytotoxic effect of the compounds examined on cancerous cell lines showed that the complex exhibited substantial anticancer activity.
Synthesis, structural, spectroscopic and biological studies of Schiff base complexes
Diab,El-Sonbati,Shoair,Eldesoky,El-Far
, p. 710 - 739 (2017)
Schiff base ligand 4-((pyridin-2- yl)methyleneamino)-1,2-dihydro-2,3-dimethyl-1-phenylpyrazol-5-one (PDMP) and its complexes were prepared and characterized on the basis of elemental analysis, IR, mass spectra and thermogravimetric analysis. All results confirm that the complexes have 1:1 (M: PMDP) stoichiometric formula [M(PMDP)Cl2H2O ] (M?=?Cu(II), Co(II), Ni(II) and Mn(II)), [Cd(PMDP)Cl2] and the ligand behaves as a bi/tridentate forming five-membered chelating ring towards the metal ions, bonding through azomethine nitrogen/exocyclic carbonyl oxygen, azomethine pyridine nitrogen and exocyclic carbonyl oxygen. The shift in the band positions of the groups involved in coordination has been utilized to estimate the metal-nitrogen and/or oxygen bond lengths. The complexes of Co(II), Ni(II) and Cu(II) are paramagnetic and the magnetic as well as spectral data suggest octahedral geometry, whereas the Cd(II) complex is tetrahedral. The XRD studies show that both the ligand and its metal complexes (1 and 3) show polycrystalline with crystal structure. Molecular docking was used to predict the binding between PMDP ligand and the receptors. The corrosion inhibition of mild steel in 2?M HCl solution by PDMP was explored utilizing potentiodynamic polarization, electrochemical impedance spectroscopy (EIS) and (EFM) electrochemical frequency modulation method. Potentiodynamic polarization demonstrated that PDMP compound is mixed-type inhibitor. EIS spectra exhibit one capacitive loop and confirm the protective ability. The percentage of inhibition efficiency was found to increase with increasing the inhibitor concentration.
A highly selective fluorescent probe for Al3+ based on 4-aminoantipyrine
Zhou, Yanmei,Zhang, Junli,Zhou, Hua,Hu, Xiaoyi,Zhang, Lin,Zhang, Min
, p. 68 - 72 (2013/04/23)
A novel and simple Schiff base based on 2-pyridine formaldehyde and 4-aminoantipyrine was synthesized and characterized as a fluorescent probe. In the presence of Al3+, the fluorescent intensity has a dramatic enhancement over other examined metal ions in aqueous solution. The method of Job's plot indicated the formation of 1:1 complex between probe and Al 3+, and the possible binding mode of the system was also proposed. Moreover, other examined metal ions had no effect on the detection of Al 3+.
