6972-79-8

Basic information

• Product Name: 1,3-BIS(BENZYLOXY)-2-PROPANOL
• Synonyms: 1,3-BIS(BENZYLOXY)-2-PROPANOL;1,3-DI-O-BENZYLGLYCEROL;1,3-DIBENZYLOXY-2-PROPANOL;1,3-Dibenzylglycerol (DBG);1,3-Benzyloxy-2-propanol;1,3-Bis(phenylmethoxy)-2-propanol;1,3-Dibenzylglycerin;1,3-Dibenzyloxy-2-hydroxypropane
• CAS NO: 6972-79-8
• Molecular Formula: C₁₇H₂₀O₃
• Molecular Weight: 272.34
• Product Categories: All Aliphatics;Aliphatics;Aromatics;Intermediates
• Mol File: 6972-79-8.mol
• Article Data: 40

Chemical Properties

• Boiling Point: 226-227 °C3 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: Pale-Yellow Oil
• Density: 1.103 g/mL at 20 °C(lit.)
• Vapor Pressure: 1.42E-07mmHg at 25°C
• Refractive Index: n20/D 1.549(lit.)
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 13.62±0.20(Predicted)
• BRN: 1986774
• CAS DataBase Reference: 1,3-BIS(BENZYLOXY)-2-PROPANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-BIS(BENZYLOXY)-2-PROPANOL(6972-79-8)
• EPA Substance Registry System: 1,3-BIS(BENZYLOXY)-2-PROPANOL(6972-79-8)

Safety Data

• Safety Statements: 23-24/25
• WGK Germany: 3
• Hazardous Substances Data: 6972-79-8(Hazardous Substances Data)

Usage

Chemical Properties

Pale-Yellow Oil

Uses

Different sources of media describe the Uses of 6972-79-8 differently. You can refer to the following data:
1. 1,3-Dibenzyloxy-2-propanol was used in the synthesis of 1,3-dibenzyloxyacetone. It was also used as precursor to antiviral intermediates.
2. Having spasmolytic and cholinolytic activity

InChI:InChI=1/C17H20O3/c18-17(13-19-11-15-7-3-1-4-8-15)14-20-12-16-9-5-2-6-10-16/h1-10,17-18H,11-14H2

Upstream product

• 96-23-1 1,3-Dichloro-2-propanol 
• 100-44-7 benzyl chloride 
• 56-81-5 glycerol 
• 56552-80-8 (R)-3-benzyloxy-1,2-propanediol 
• 100-51-6 benzyl alcohol 
• 13071-59-5 3-benzyloxypropan-1,2-diol 
• 100-39-0 benzyl bromide 
• 106-89-8 epichlorohydrin 
• 1708-39-0 (S)-1,2-O-benzylideneglycerol 
• 1708-40-3 2-phenyl-[1,3]dioxan-5-ol 
• 100-52-7 benzaldehyde 
• 1708-39-0 1,2-benzylideneglycerol 
• 51164-00-2 4-Benzyloxymethyl-2-phenyl-[1,3]dioxolane 
• 20194-18-7 sodium phenyl-methanolate 

Downstream Products

• 22598-15-8 1,3-bis-benzyloxy-2-tetradecyloxy-propane 
• 97083-33-5 1,3-Dibenzyloxy-2--propan 
• 96002-61-8 2-Butyloxymethoxy-1,3-dibenzyloxy-propan 
• 22598-14-7 1,3-bis-benzyloxy-2-methoxy-propane 
• 74564-16-2 1,3-dibenzyloxy-2-(chloromethoxy)propane 
• 137500-29-9 1,3-dibenzyloxy-2-propyl acetate 
• 112475-10-2 2-benzyloxy-1-benzyloxymethylethoxyacetonitrile 
• 138208-14-7 1,9-di-O-benzyl-2,8-bis(benzyloxymethyl)-3,7-dioxanonane 
• 213026-99-4 2-(2-Benzyloxy-1-benzyloxymethyl-ethyl)-isoindole-1,3-dione 
• 213265-19-1 (2S,3R,4S,5R,6R)-3,4,5-Tris-benzyloxy-2-(2-benzyloxy-1-benzyloxymethyl-ethoxy)-6-benzyloxymethyl-tetrahydro-pyran 
• 444808-91-7 1,3-di-O-benzyl-2-O-β-D-(galactopyranosyl)-glycerol 
• 74554-15-7 9-<<2-benzyloxy-1-(benzyloxymethyl)ethoxy>methyl>adenine 
• 112474-99-4 2-benzyloxy-1-benzyloxymethylethoxyacetamide 
• 112475-01-1 2-benzyloxy-1-benzyloxymethylethoxythioacetamide 

Relevant articles and documents

Characterization of hydrazine derivative: Proposed decomposition mechanism and structure elucidation of decomposition compounds

Decomposition of protected hydrazine diol (1) hemi-oxalate, a key intermediate of the potent indolocarbazole-based DNA topoisomerase I inhibitor (2), was investigated. Spectroscopic analysis revealed that the main decomposition compounds of the hydrazine

Selective catalytic oxidation of diglycerol

The selective oxidation of α,α-diglycerol was studied using oxygen as a clean oxidant in the presence of a palladium/neocuproine complex. After optimization of the reaction parameters, the mono-oxidation product was obtained with 93% NMR yield (up to 76% isolated yield). The product was named “diglycerose” considering that it mainly exists as a cyclic hemi-ketal form.

Glycerol etherification with benzyl alcohol over sulfated zirconia catalysts

Glycerol (GLY) etherification with benzyl alcohol (BA) was conducted with different zirconia-based heterogeneous acid catalysts, aiming to produce mono- (ME) and dibenzyl glycerol ethers (DE). Physicochemical properties of the prepared catalysts were obtained through XRD, SEM and adsorption of ammonia. The catalytic tests were performed at different temperatures (120-140°C) and initial reactant mass ratios (GLY:BA 1:1 and 2:1). The highest BA conversions were obtained with the catalyst having the highest sulfuric acid content (2S/ZrO2). An increase in the reaction temperature and the GLY:BA initial mass ratio led to an increase in the BA conversion. Two kinetic models (a potential and a hyperbolic approach) were proposed to describe the process performance, including not only reactants evolution with time, but also that of ME, DE and the undesired self-condensation product of BA (benzyl ether, BE). Kinetic parameters for each model were estimated by data fitting and both models were able to accurately describe the evolution of the system, in terms of reactants and product distribution as a function of time under the experimental conditions studied.