69304-44-5

Basic information

• Product Name: 3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)guanosine
• Synonyms: 3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disoloxanediyl)guanosine;3',5'-TIPS-guanosine;3',5'-O-(1,1,3,3-TETRAISOPROPYLDISILOXAN-1,3-DIYL)-GUANOSINE;3',5'-(TETRAISOPROPYL-DISILOXANE-1,3-DIYL)-GUANOSINE;3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)guanosine
• CAS NO: 69304-44-5
• Molecular Formula: C₂₂H₃₉N₅O₆Si₂
• Molecular Weight: 525.75
• Product Categories: Nucleosides
• Mol File: 69304-44-5.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)guanosine(CAS DataBase Reference)
• NIST Chemistry Reference: 3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)guanosine(69304-44-5)
• EPA Substance Registry System: 3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)guanosine(69304-44-5)

Safety Data

• Hazardous Substances Data: 69304-44-5(Hazardous Substances Data)

Usage

Description

3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)guanosine is a silicon-containing hindered nucleoside with a unique structure that exhibits antiviral properties. It is characterized by the presence of a 1,1,3,3-tetraisopropyl-1,3-disiloxane moiety attached to the guanosine molecule, which contributes to its stability and activity against certain viruses.

Uses

Used in Antiviral Applications:
3',5'-O-(1,1,3,3-Tetraisopropyl-1,1-disiloxanediyl)guanosine is used as an antiflaviviridae agent for the treatment of viral infections caused by BVDV (Bovine Viral Diarrhea Virus), YFV (Yellow Fever Virus), DENV (Dengue Virus), and WNV (West Nile Virus). Its antiviral activity is demonstrated in cell-based assays, where it effectively inhibits the replication and spread of these viruses.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)guanosine is used as a key component in the development of antiviral drugs targeting Flaviviridae family viruses. Its unique structure and antiviral properties make it a promising candidate for the creation of new therapeutic agents to combat viral diseases.
Used in Research and Development:
3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)guanosine is also utilized in research and development for the study of viral mechanisms and the development of novel antiviral strategies. Its application in cell-based assays allows researchers to investigate the compound's mode of action and potential synergistic effects with other antiviral agents, leading to the discovery of more effective treatments for viral infections.

Upstream product

• 18173-84-7 diisopropylsilanol 
• 18043-71-5 1,1,3,3-tetraisopropyldisiloxane 
• 69304-37-6 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane 
• 118-00-3 guanosine 
• 87865-78-9 3',5'-O-(1,1,3,3-tetraisopropyldisiloxan-1,3-diyl)-N₂-isobutyrylguanosine 
• 118-00-3 G 

Downstream Products

• 38819-10-2 9-β-D-arabinofuranosylguanine 
• 90813-68-6 2'-O-methylthylthiomethylguanosine 
• 73-40-5 2-amino-1,9-dihydro-6H-purin-6-one 
• 92544-22-4 2-methylene-3(2H)-furanone 
• 1620667-58-4 C₁₀H₁₃ClN₅O₇P 
• 1620667-59-5 2'-chloro-2'-deoxyguanosine-5'-monophosphate 
• 1355611-05-0 C₆H₁₅N*C₄₈H₄₆ClN₁₀O₁₁P 
• 1355611-03-8 C₄₂H₄₂N₁₀O₈ 
• 1355611-02-7 C₂₁H₂₄N₁₀O₆ 
• 1355611-01-6 C₃₃H₅₀N₁₀O₇Si₂ 
• 1355611-00-5 C₃₄H₅₀F₃N₇O₁₀SSi₂ 
• 1355610-99-9 C₃₃H₅₁N₇O₈Si₂ 
• 1355610-98-8 C₃₄H₅₀F₃N₇O₁₀SSi₂ 
• 1207451-97-5 C₂₉H₄₅N₅O₈SSi₂ 

Relevant articles and documents

Partial Synthesis of Leader Sequence of Phage f1 Coat Protein mRNA

Tetra to undecaribonucleotides of the leader sequence in messenger RNA(mRNA) of f1 coat protein were synthesized on a polystyrene solid support through simple phosphotriester approach.

SPIROTHIETANE NUCLEOSIDES

The present invention relates to 2'-spirothietane nucleosides, and the phosphates and the prodrugs thereof, and the pharmaceutically acceptable salts and solvates thereof, and the use of such compounds as a medicament, in particular in the prevention and/or treatment of viral infections caused by viruses belonging to the Flaviviridae family and/or to the alphavirus genus. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, and to the compositions or preparations for use as a medicament, more preferably for the prevention or treatment of viral infections caused by viruses belonging to the Flaviviridae family and/or to the alphavirus genus. The invention also relates to processes for the preparation of the compounds.

Molybdopterin biosynthesis: Trapping of intermediates for the MoaA-catalyzed reaction using 2′-deoxyGTP and 2′-chloroGTP as substrate analogues.

MoaA is a radical S-adenosylmethionine (AdoMet) enzyme that catalyzes a complex rearrangement of guanosine-5'-triphosphate (GTP) in the first step of molybdopterin biosynthesis. In this paper, we provide additional characterization of the MoaA reaction product, describe the use of 2′-chloroGTP to trap the GTP C3′ radical, generated by hydrogen atom transfer to the 5′-deoxyadenosyl radical, and the use of 2′-deoxyGTP to block a late step in the reaction sequence. These probes, coupled with the previously reported trapping of an intermediate in which C3′ of the ribose is linked to C8 of the purine, allow us to propose a plausible mechanism for the MoaA-catalyzed reaction.