6928-85-4 Usage
Description
1-Amino-4-methylpiperazine, a derivative of piperazine, is a clear colorless to light yellow liquid. It is widely used as an intermediate in the synthesis of various pharmaceutical agents, including Rifampicin, an antibiotic used to treat several types of bacterial infections such as tuberculosis, leprosy, and Legionnaire's disease.
Uses
1. Used in Pharmaceutical Synthesis:
1-Amino-4-methylpiperazine is used as an intermediate for the synthesis of various pharmaceutical agents, including Rifampicin, an antibiotic effective against tuberculosis, leprosy, and Legionnaire's disease.
2. Used in Chemical Synthesis:
1-Amino-4-methylpiperazine is used as a solvating and stabilizing agent in the preparation of uniform Ag nanoparticles (<10nm) and in the synthesis of various compounds, such as:
Pyrazolo-pyrazine and pyridine derivatives
2-[(4-methylpiperazin-1-yl)iminomethyl]phenol
N-(4-Fluorobenzylidene)-4-methylpiperazin-1-amine
4-Methyl-N-(3,4,5-trimethoxybenzylidene)piperazin-1-amine
N-(3,4-Dichlorobenzylidene)-4-methylpiperazin-1-amine
N-(4-(Diethylamino)benzylidene)-4-methylpiperazin-1-amine
N-(2,5-Dimethoxybenzylidene)-4-methylpiperazin-1-amine
4-Methyl-N-((5-nitrofuran-2-yl)methylene)piperazin-1-amine
These applications highlight the versatility of 1-Amino-4-methylpiperazine in different industries, particularly in the pharmaceutical and chemical synthesis sectors.
Preparation
1-Amino-4-methylpiperazine is obtained from piperazine hexahydrate through the steps of methylation, hydrolysis, nitrosation and reduction.1-Amino-4-methylpiperazine is synthesized by chlorination of methyl(diethanol)amine (I) and subsequent cyclization of the di(chloroethyl)amine (II) obtained in aqueous hydrazine.
Flammability and Explosibility
Notclassified
Check Digit Verification of cas no
The CAS Registry Mumber 6928-85-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,9,2 and 8 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 6928-85:
(6*6)+(5*9)+(4*2)+(3*8)+(2*8)+(1*5)=134
134 % 10 = 4
So 6928-85-4 is a valid CAS Registry Number.
InChI:InChI=1/C5H13N3/c1-7-2-4-8(6)5-3-7/h2-6H2,1H3
6928-85-4Relevant articles and documents
Cyclization of N,N-bis(2-chloroethyl)methylamine in aqueous hydrazine
Kushakova,Kuznetsov,Chernobroviy,Garabadgiu
, p. 960 - 961 (2004)
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Method for synthesizing 1-amino-4-methylpiperazine through catalytic hydrogenation
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Paragraph 0047-0062; 0068, (2020/07/28)
The invention relates to a method for synthesizing 1-amino-4-methylpiperazine through catalytic hydrogenation. The invention discloses the green synthesis method for synthesizing 1-amino-4-methylpiperazine by hydrogenating 1-methyl-4-nitrosopiperazine in a water and organic mixed solvent system under the catalysis of an iron oxide and ferrous oxide supported palladium catalyst, wherein the methodcomprises the steps: adding 1-methyl-4-nitrosopiperazine into a paramagnetic Pd/Fe3O4-FeO catalyst, carrying out a hydrogenation reaction in a three-phase system of water, an organic solvent and the catalyst at a certain temperature, and finally, carrying out reduced pressure distillation separation to obtain the target product 1-amino-4-methylpiperazine. The 1-amino-4-methylpiperazine is preparedby innovatively using a catalytic hydrogenation method in a three-phase system, and compared with a traditional synthesis method, the method is more environmentally friendly and safer, and the cost is saved.
Oxazolidinone compound containing combined aromatic hydrazine and its preparation method
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Paragraph 0121-0122, (2018/04/03)
The invention relates to oxazolidinone compound containing combined aromatic hydrazine shown in general formula I, its optical isomer, pharmaceutical acceptable salt and/or solvent compound, and it preparation method, and the drug composition containing the compound, wherein the substituent groups R1, R2, R3, X and A rings have the meaning given in the specification. The invention further relatesto the compound, the substituent group, solvent compound or application of its prodrug using as antibacterial drug in treatment, and application of treating gram positive bacterial infection and mycobacterium tuberculosis infection especially.