692746-94-4

Basic information

• Product Name: N-benzyl-2-bromo-5-nitrobenzeneamine
• Synonyms: N-benzyl-2-bromo-5-nitrobenzeneamine
• CAS NO: 692746-94-4
• Molecular Weight: 307.147
• Mol File: 692746-94-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-benzyl-2-bromo-5-nitrobenzeneamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-2-bromo-5-nitrobenzeneamine(692746-94-4)
• EPA Substance Registry System: N-benzyl-2-bromo-5-nitrobenzeneamine(692746-94-4)

Safety Data

• Hazardous Substances Data: 692746-94-4(Hazardous Substances Data)

Upstream product

• 10403-47-1 2-bromo 5-nitroaniline 
• 501-53-1 benzyl chloroformate 
• 100-39-0 benzyl bromide 

Downstream Products

• 1048344-47-3 1-benzyl-1-(2-bromo-5-nitrophenyl)urea 
• 1224738-14-0 (E)-methyl 3-(2-(benzylamino)-4-nitrophenyl)acrylate 

Relevant articles and documents

Rhodium-catalyzed domino conjugate addition-cyclization reactions for the synthesis of a variety of N- and O-heterocycles: Arylboroxines as effective carbon nucleophiles

Facile and efficient Rh(I)-catalyzed domino conjugate addition-cyclization reactions of olefins bearing two electrophilic sites and a pendant nucleophile with organoboroxines have been developed to afford a variety of N- and O-heterocycles, such as 3,4-dihydroquinolin-2(1H)-ones, 3,4-dihydrocoumarins, and pyrrolidin-2-ones, which constitute important motifs in biologically active natural and synthetic organic compounds.

Synthesis of N-Benzylated Anilines from the Reaction of Anilines and Benzyl Chloroformate

Reactions of benzyl chloroformate with a series of substituted anilines produced N-carbobenzyloxy "CBZ" products along with the unexpected N-benzylated "Bn" compounds. Reaction of aniline, 1a, gave the CBZ, or 2a, and Bn, or 3a, products in 29% and 14% yi