690632-00-9 Usage
Description
5-BROMO-2,3-DIHYDROBENZO[B]FURAN-7-SULFONYL CHLORIDE is a sulfonyl chloride derivative with the molecular formula C8H6BrClO3S. It features a furan ring and a bromine atom, making it a versatile building block in organic synthesis.
Used in Pharmaceutical Industry:
5-BROMO-2,3-DIHYDROBENZO[B]FURAN-7-SULFONYL CHLORIDE is used as an intermediate in organic synthesis for the production of various pharmaceuticals. It contributes to the development of a wide range of bioactive compounds due to its unique chemical structure.
Used in Agrochemical Industry:
In the agrochemical field, 5-BROMO-2,3-DIHYDROBENZO[B]FURAN-7-SULFONYL CHLORIDE serves as a key intermediate in the synthesis of different agrochemicals, playing a crucial role in the creation of effective products for agricultural applications.
Used in Material Science:
5-BROMO-2,3-DIHYDROBENZO[B]FURAN-7-SULFONYL CHLORIDE is also utilized in material science for the production of various organic materials. Its chemical properties allow it to be a valuable component in the development of innovative materials with specific properties.
Check Digit Verification of cas no
The CAS Registry Mumber 690632-00-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,9,0,6,3 and 2 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 690632-00:
(8*6)+(7*9)+(6*0)+(5*6)+(4*3)+(3*2)+(2*0)+(1*0)=159
159 % 10 = 9
So 690632-00-9 is a valid CAS Registry Number.
InChI:InChI=1/C8H6BrClO3S/c9-6-3-5-1-2-13-8(5)7(4-6)14(10,11)12/h3-4H,1-2H2
690632-00-9Relevant articles and documents
Synthesis, evaluation and in silico studies of novel BRD4 bromodomain inhibitors bearing a benzo[d]isoxazol scaffold
Zhang, Maofeng,Liu, Zhuyun,Wang, Lizhong,Li, Yan,Ma, Yonggang
, (2021/02/12)
Abstract: The BRD4 protein is associated with various diseases, which has been an attractive target for the treatment of cancer and inflammation. This paper is a follow-up to our previous studies, in which we report the structure-based design, synthesis, and evaluation of a new class of small-molecule BRD4 bromodomain inhibitors bearing a benzo[d]isoxazol scaffold. The SARs focused on exploration of the 2′ or 3′ position to afford novel inhibitors that may avoid potential metabolically unstable site. The most potent inhibitor 13f exhibited high binding affinity to BRD4(1) with a ΔTm value of 7.8 °C as evaluated in thermal shift assay (TSA). The potent activity was also demonstrated by a peptide competition assay with an IC50 value of 0.21?μM. The docking studies revealed the binding mode of the compounds with the active site of BRD4(1). In addition, in silico predictions indicated that these compounds possessed good drug-likeness and pharmacokinetic profile. Graphic abstract: This paper is a follow-up to our previous studies, in which we report the structure-based design,synthesis, and evaluation of a new class of small-molecule BRD4 bromodomain inhibitors bearing a benzo[d]isoxazolscaffold.[Figure not available: see fulltext.].
COMPOUNDS
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Page/Page column 108, (2020/01/11)
A compound of formula (I), or a pharmaceutical salt thereof.