6877-32-3 Usage
Description
Corynoxine is an indole alkaloid that is extracted from Uncaria plants. It has been demonstrated to influence the locomotor response in mice, with research indicating that its effects are mediated through the central dopaminergic system.
Uses
Used in Pharmaceutical Industry:
Corynoxine is used as a pharmaceutical agent for its potential influence on the central dopaminergic system. This makes it a candidate for the development of treatments targeting conditions related to dopamine dysregulation, such as certain neurological or psychiatric disorders.
Used in Research Applications:
In the field of scientific research, Corynoxine is utilized as a research tool to study the effects of indole alkaloids on the central nervous system, particularly in relation to locomotor activity and dopaminergic pathways. This can aid in understanding the mechanisms of action and potential therapeutic applications of similar compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 6877-32-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,8,7 and 7 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 6877-32:
(6*6)+(5*8)+(4*7)+(3*7)+(2*3)+(1*2)=133
133 % 10 = 3
So 6877-32-3 is a valid CAS Registry Number.
InChI:InChI=1/C22H28N2O4/c1-4-14-12-24-10-9-22(17-7-5-6-8-18(17)23-21(22)26)19(24)11-15(14)16(13-27-2)20(25)28-3/h5-8,13-15,19H,4,9-12H2,1-3H3,(H,23,26)/b16-13+/t14-,15+,19+,22+/m1/s1
6877-32-3Relevant articles and documents
Total synthesis of the spirocyclic oxindole alkaloids corynoxine, corynoxine B, corynoxeine, and rhynchophylline
Wanner, Martin J.,Ingemann, Steen,Van Maarseveen, Jan H.,Hiemstra, Henk
, p. 1100 - 1106 (2013/03/29)
Racemic total syntheses of four spirocyclic oxindole alkaloids are reported. The general starting material was an N-2-butenylated 2-hydroxytryptamine, which underwent a base-mediated Mannich spirocyclisation with a functionalised aldehyde to generate the C-ring. The second key step was a Pd-catalysed cyclisation of an α-keto ester enolate (in the original aldehyde) onto an allylic carbonate (in the N-substituent) to form the D-ring. The stereoselectivities of the key steps were moderate, but the isomers were readily purified, so that the natural products could be conveniently prepared, three of them for the first time. Racemic total syntheses of the four title spirocyclic oxindole alkaloids are reported starting from 4-hydroxytryptamine. The key steps were a base-mediated Mannich spirocyclisation to form the C-ring, and a Pd-catalysed cyclisation of a keto ester enolate onto an allylic carbonate to form the D-ring. Thus, convenient syntheses of the alkaloids were achieved, for three of them for the first time. Copyright
