685-91-6Relevant articles and documents
One-Pot Synthesis of Tertiary Amides from Organic Trichlorides through Oxygen Atom Incorporation from Air by Convergent Paired Electrolysis
Luo, Zhongli,Imamura, Kenji,Shiota, Yoshihito,Yoshizawa, Kazunari,Hisaeda, Yoshio,Shimakoshi, Hisashi
, p. 5983 - 5990 (2021/05/04)
A convergent paired electrolysis catalyzed by a B12 complex for the one-pot synthesis of a tertiary amide from organic trichlorides (R-CCl3) has been developed. Various readily available organic trichlorides, such as benzotrichloride and its derivatives, chloroform, dichlorodiphenyltrichloroethane (DDT), trichloro-2,2,2-trifluoroethane (CFC-113a), and trichloroacetonitrile (CNCCl3), were converted to amides in the presence of tertiary amines through oxygen incorporation from air at room temperature. The amide formation mechanism in the paired electrolysis, which was mediated by a cobalt complex, was proposed.
Production method of N,N-diethyl acetamide
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Paragraph 0018; 0025; 0035; 0045; 0055; 0065; 0075, (2020/06/30)
The invention discloses a preparation method of N,N-dimethylformamide. The production method comprises the following steps: n a self-reflux reactor filled with a heterogeneous catalyst, firstly addingethyl acetate and ethylamine, carrying out heating to 30 DEG C within 10-20 minutes, then gradually adding ethanol within 20-30 minutes, then carrying out heating to 50-60 DEG C at a speed of 30-50 DEG C/h, performing reacting for 20-30 minutes, ending the reaction, and finally carrying out purifying to obtain N,N-diethyl acetamide. The obtained N,N-diethyl acetamide is high in yield, selectivityand purity, and the method is mild in reaction condition and easy to operate.
Manganese-mediated acetylation of alcohols, phenols, thiols, and amines utilizing acetic anhydride
Jain, Isha,Sharma, Ramandeep,Malik, Payal
supporting information, p. 2952 - 2960 (2019/09/13)
Manganese(II) chloride-catalyzed acetylation of alcohols, phenols thiols and amines with acetic anhydride is reported. This method is environment-friendly and economically viable as it involves inexpensive, relatively benign catalyst, mild reaction condition, and simple workup. Acetylation is performed under the solvent-free condition at ambient temperature and acetylated products obtained in good to excellent yields. Primary, secondary heterocyclic amines, and phenols with various functional groups are smoothly acetylated in good yields. This method exhibits exquisite chemoselectivity, the amino group is preferentially acetylated in the presence of a hydroxyl/thiol group.