68278-23-9 Usage
Description
Eflornithine hydrochloride, also known as DL-alpha-Difluoromethylornithine hydrochloride, is a synthetic compound that acts as an irreversible inhibitor of ornithine decarboxylase, an enzyme involved in the biosynthesis of polyamines. It has antineoplastic and antiprotozoal properties, making it a potential candidate for various medical applications.
Uses
Used in Antineoplastic Applications:
Eflornithine hydrochloride is used as an antineoplastic agent for the treatment of certain types of cancer. It works by inhibiting the enzyme ornithine decarboxylase, which is essential for the synthesis of polyamines, molecules that play a crucial role in cell growth and proliferation. By blocking this enzyme, Eflornithine hydrochloride can effectively reduce the rate of tumor growth and potentially lead to tumor regression.
Used in Antiprotozoal Applications:
Eflornithine hydrochloride is also used as an antiprotozoal agent, particularly for the treatment of African trypanosomiasis, also known as sleeping sickness. It is effective against the parasitic protozoa that cause this disease, helping to control the infection and alleviate symptoms.
Indications
Vaniqa (eflornithine hydrochloride 13.9%) cream is a unique topical cream
that slows anagen hair growth by irreversibly blocking the enzyme ornithine
decarboxylase. This enzyme produces polyamines in the hair matrix that are
partially responsible for the growth of the anagen hair. The cream was tested
only on the upper lip and chin region. The onset of action is usually within 8
weeks of starting the b.i.d. treatment, and the hair growth will return to baseline
within 8 weeks of discontinuing the drug. Patients need to be reminded that this
product does not remove hair but slows its growth in between whatever they use
for hair removal.
Check Digit Verification of cas no
The CAS Registry Mumber 68278-23-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,8,2,7 and 8 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 68278-23:
(7*6)+(6*8)+(5*2)+(4*7)+(3*8)+(2*2)+(1*3)=159
159 % 10 = 9
So 68278-23-9 is a valid CAS Registry Number.
InChI:InChI=1/C6H12F2N2O2.ClH.H2O/c7-4(8)6(10,5(11)12)2-1-3-9;;/h4H,1-3,9-10H2,(H,11,12);1H;1H2
