6807-83-6 Usage
Description
Trifolirhizin is a flavonoid compound derived from the plant Sophora flavescens, which has demonstrated cytotoxic effects on various cancer cell lines. It is a bioactive molecule with potential applications in the pharmaceutical and healthcare industries due to its ability to target and inhibit the growth of cancer cells.
Uses
Used in Pharmaceutical Industry:
TRIFOLIRHIZIN is used as a cytotoxic agent for targeting and inhibiting the growth of cancer cells. Its ability to exert cytotoxicity on several cancer cell lines makes it a promising candidate for the development of novel anticancer drugs and therapies.
Used in Cancer Research:
TRIFOLIRHIZIN is used as a research tool for studying the mechanisms underlying its cytotoxic effects on cancer cells. This can help in understanding the molecular pathways involved in cancer cell growth and the potential of TRIFOLIRHIZIN as a therapeutic agent in cancer treatment.
Used in Drug Development:
TRIFOLIRHIZIN is used as a lead compound in the development of new drugs targeting cancer cells. Its cytotoxic properties can be further optimized and combined with other therapeutic agents to enhance the overall effectiveness of cancer treatments.
Used in Drug Delivery Systems:
TRIFOLIRHIZIN can be used as an active ingredient in the development of drug delivery systems, such as nanoparticles or liposomes, to improve its bioavailability, targeting, and therapeutic efficacy in cancer treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 6807-83-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,8,0 and 7 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 6807-83:
(6*6)+(5*8)+(4*0)+(3*7)+(2*8)+(1*3)=116
116 % 10 = 6
So 6807-83-6 is a valid CAS Registry Number.
InChI:InChI=1/C22H22O10/c23-6-17-18(24)19(25)20(26)22(32-17)30-9-1-2-10-13(3-9)27-7-12-11-4-15-16(29-8-28-15)5-14(11)31-21(10)12/h1-5,12,17-26H,6-8H2/t12-,17+,18+,19-,20+,21-,22+/m0/s1
6807-83-6Relevant articles and documents
Molecular and Structural Characterization of a Promiscuous C-Glycosyltransferase from Trollius chinensis
He, Jun-Bin,Zhao, Peng,Hu, Zhi-Min,Liu, Shuang,Kuang, Yi,Zhang, Meng,Li, Bin,Yun, Cai-Hong,Qiao, Xue,Ye, Min
supporting information, p. 11513 - 11520 (2019/07/16)
Herein, the catalytic promiscuity of TcCGT1, a new C-glycosyltransferase (CGT) from the medicinal plant Trollius chinensis is explored. TcCGT1 could efficiently and regio-specifically catalyze the 8-C-glycosylation of 36 flavones and other flavonoids and could also catalyze the O-glycosylation of diverse phenolics. The crystal structure of TcCGT1 in complex with uridine diphosphate was determined at 1.85 ? resolution. Molecular docking revealed a new model for the catalytic mechanism of TcCGT1, which is initiated by the spontaneous deprotonation of the substrate. The spacious binding pocket explains the substrate promiscuity, and the binding pose of the substrate determines C- or O-glycosylation activity. Site-directed mutagenesis at two residues (I94E and G284K) switched C- to O-glycosylation. TcCGT1 is the first plant CGT with a crystal structure and the first flavone 8-C-glycosyltransferase described. This provides a basis for designing efficient glycosylation biocatalysts.
A TRIFOLIRHIZIN MALONATE FROM SOPHORA FLAVESCENS VAR. ANGUSTIFOLIA AND ITS STABILITY
Yamamoto, Hirobumi,Ichimura, Masahiko,Tanaka, Toshiyuki,Iinuma, Munekazu,Mizuno, Mizuo
, p. 1732 - 1733 (2007/10/02)
Trifolirhizin 6''-O-malonate was isolated both from the roots and callus cultures of Sophora flavescens var. angustifolia and identified by HPLC, MS and NMR.
