676560-85-3

Basic information

• Product Name: (2S,5S)-ethyl 5-methylpyrrolidine-2-carboxylate 2,2,2- trifluoro acetate salt
• Synonyms: (2S,5S)-ethyl 5-methylpyrrolidine-2-carboxylate 2,2,2- trifluoro acetate salt;(2S,5S)-ethyl 5-methylpyrrolidine-2-carboxylate 2,2,2-trifluoroacetate;Velpatasvir Intermediate 4
• CAS NO: 676560-85-3
• Molecular Formula: C₂HF₃O₂*C₈H₁₅NO₂
• Molecular Weight: 271.24
• Mol File: 676560-85-3.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2S,5S)-ethyl 5-methylpyrrolidine-2-carboxylate 2,2,2- trifluoro acetate salt(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,5S)-ethyl 5-methylpyrrolidine-2-carboxylate 2,2,2- trifluoro acetate salt(676560-85-3)
• EPA Substance Registry System: (2S,5S)-ethyl 5-methylpyrrolidine-2-carboxylate 2,2,2- trifluoro acetate salt(676560-85-3)

Safety Data

• Hazardous Substances Data: 676560-85-3(Hazardous Substances Data)

Usage

General Description

The chemical (2S,5S)-ethyl 5-methylpyrrolidine-2-carboxylate 2,2,2-trifluoro acetate salt is a compound that is used in organic synthesis and pharmaceutical research. It is an ester derivative of a pyrrolidine carboxylic acid, and it is typically found in the form of a salt with trifluoroacetate. (2S,5S)-ethyl 5-methylpyrrolidine-2-carboxylate 2,2,2- trifluoro acetate salt has potential applications in the development of new drugs and pharmaceuticals due to its unique chemical structure and properties. It may be used as a building block in the synthesis of complex organic molecules, and its trifluoroacetate salt form may contribute to its stability and solubility in certain chemical environments. Overall, this chemical compound has potential utility in the field of pharmaceutical research and development.

Upstream product

• 1448310-17-5 (S)-ethyl 5-methyl-3,4-dihydro-2H-pyrrole-2-carboxylate 2,2,2-trifluoro acetate salt 
• 913251-58-8 (S)-2-(tert-butoxycarbonylamino)-5-oxohexanoic acid ethyl ester 
• 144978-35-8 (S)-ethyl N-tert-butoxycarbonylpyroglutamate 

Downstream Products

• 676560-83-1 (2S,5S)-5-methyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester 
• 1335316-35-2 tert-butyl (2S,5S)-2-[4-[4-[4-[2-[(2S,5S)-1-[2-(methoxycarbonylamino)-3-methyl-butanoyl]-5-methyl-pyrrolidin-2-yl]-1H-benzimidazol-5-yl]phenyl]phenyl]-1H-imidazol-2-yl]-5-methyl-pyrrolidine-1-carboxylate 
• 1335316-38-5 methyl N-[2-methyl-1-[(2S,5S)-2-methyl-5-[4-[4-[4-[2-[(2S,5S)-5-methylpyrrolidin-2-yl]-1H-imidazol-5-yl]phenyl]phenyl]-1H-benzimidazol-2-yl]pyrrolidine-1-carbonyl]propyl]-carbamate 
• 1335315-74-6 methyl N-[(1S)-1-[(2S,5S)-2-[4-[4-[4-[2-[(2S,5S)-1-[2-(methoxycarbonylamino)-3-methyl-butanoyl]-5-methyl-pyrrolidin-2-yl]-1H-benzimidazol-5-yl]phenyl]phenyl]-1H-imidazol-2-yl]-5-methyl-pyrrolidine-1-carbonyl]-2-methyl-propyl]carbamate 
• 1335316-40-9 (2S,5S)-1-((S)-2-(methoxycarbonylamino)-3-methylbutanoyl)-5-methylpyrrolidine-2-carboxylic acid 
• 1448309-79-2 (2S,5S)-N-((R)-1-(2-chlorophenyl)-2-(4,4-difluorocyclohexylamino)-2-oxoethyl)-N-(3-fluorophenyl)-5-methyl-1-(pyrimidin-2-yl)pyrrolidine-2-carboxamide 
• 1448309-80-5 (2S,5S)-N-((S)-1-(2-chlorophenyl)-2-(4,4-difluorocyclohexylamino)-2-oxo ethyl)-N-(3-fluorophenyl)-5-methyl-1-(pyrimidin-2-yl)pyrrolidine-2-carboxamide 
• 1378391-43-5 (2R,4R)-1-tert-butyl 2-(2-(9-((2S,5S)-1-((S)-2-(methoxycarbonylamino)-3-methylbutanoyl)-5-methylpyrrolidine-2-carbonyloxy)-8-oxo-8,9,10,11-tetrahydro-5H-dibenzo[c,g]chromen-3-yl)-2-oxoethyl) 4-(methoxymethyl)pyrrolidine-1,2-dicarboxylate 
• 725265-95-2 4-phenylbutanoyl-5(S)-methyl-L-proline ethyl ester 

Relevant articles and documents

THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE

Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.

COMPOUNDS HAVING PROLYL OLIGOPEPTIDASE INHIBITORY ACTIVITY

The invention provides a compound of formula (I), wherein in the formula X, R1, R2 and R3 are as defined in claim 1, or a pharmaceutically acceptable salt or ester thereof, useful as a prolyl oligopeptidase inhibitor. The compounds of formula (I) can be used for the treatment of diseases or conditions where prolyl oligopeptidase inhibitors are indicated to be effective, for example for the treatment of neurodegenerative diseases, such as Alzheimer's disease and senile dementia