6750-85-2

Basic information

• Product Name: 5-(Methoxycarbonyl)furan-2-carboxylic acid
• Synonyms: 5-(Methoxycarbonyl)furan-2-carboxylic acid
• CAS NO: 6750-85-2
• Molecular Formula: C₇H₆O₅
• Molecular Weight: 170.11954
• Mol File: 6750-85-2.mol
• Article Data: 17

Chemical Properties

• Melting Point: 201 °C
• Boiling Point: 344.6±27.0 °C(Predicted)
• Appearance: /
• Density: 1.387±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 2.55±0.10(Predicted)
• CAS DataBase Reference: 5-(Methoxycarbonyl)furan-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(Methoxycarbonyl)furan-2-carboxylic acid(6750-85-2)
• EPA Substance Registry System: 5-(Methoxycarbonyl)furan-2-carboxylic acid(6750-85-2)

Safety Data

• Hazardous Substances Data: 6750-85-2(Hazardous Substances Data)

Usage

Description

5-(Methoxycarbonyl)furan-2-carboxylic acid is a chemical compound characterized by the molecular formula C8H6O5. It is a derivative of furan-2-carboxylic acid, featuring a methoxycarbonyl group attached at the 5th position. This white to off-white powder is soluble in organic solvents but exhibits slight solubility in water. The presence of the methoxycarbonyl group endows the molecule with unique reactivity, making it a valuable building block for the synthesis of pharmaceuticals, organic compounds, and other applications in fields such as agriculture and material science.

Uses

Used in Pharmaceutical Synthesis:
5-(Methoxycarbonyl)furan-2-carboxylic acid is utilized as a key intermediate in the synthesis of various pharmaceuticals. Its unique reactivity and structural features make it a versatile building block for the development of new drugs with potential therapeutic applications.
Used in Organic Compounds Synthesis:
In the field of organic chemistry, 5-(Methoxycarbonyl)furan-2-carboxylic acid serves as a valuable precursor for the synthesis of a wide range of organic compounds. Its methoxycarbonyl group allows for various chemical reactions, facilitating the creation of complex molecules with diverse properties.
Used in Agricultural Applications:
5-(Methoxycarbonyl)furan-2-carboxylic acid has potential applications in agriculture, where it may be used as a component in the development of new agrochemicals or as a building block for the synthesis of bioactive compounds with pesticidal or herbicidal properties.
Used in Material Science:
In the realm of material science, 5-(Methoxycarbonyl)furan-2-carboxylic acid can be employed in the synthesis of novel materials with specific properties. Its unique chemical structure and reactivity may contribute to the development of advanced materials for various applications, such as sensors, coatings, or polymers with tailored characteristics.

Upstream product

• 1917-64-2 5-(methoxymethyl)-2-furaldehyde 
• 3238-40-2 furan-2,5-dicarboxylic acid 
• 485-80-3 S-adenosyl-L-methionine 
• 36802-01-4 Methyl ester of 5-hydroxymethylfuran 2-carboxylic acid 
• 90-80-2 D-Glucono-1,5-lactone 
• 61259-48-1 2,3,4,6-tetra-O-acetyl-D-glucono-1,5-lactone 
• 2527-96-0 methyl 5-methyl-2-furancarboxylate 
• 67-56-1 methanol 
• 67-47-0 5-hydroxymethyl-2-furfuraldehyde 
• 149-73-5 trimethyl orthoformate 
• 823-82-5 2,5-diformylfurane 

Downstream Products

• 633333-44-5 5-[(benzyloxy)carbonyl]furan-2-carboxylic acid 
• 3238-40-2 furan-2,5-dicarboxylic acid 
• 4282-32-0 furan-2,5-dicarboxylic acid dimethyl ester 

Relevant articles and documents

Carboxyl Methyltransferase Catalysed Formation of Mono- and Dimethyl Esters under Aqueous Conditions: Application in Cascade Biocatalysis

Carboxyl methyltransferase (CMT) enzymes catalyse the biomethylation of carboxylic acids under aqueous conditions and have potential for use in synthetic enzyme cascades. Herein we report that the enzyme FtpM from Aspergillus fumigatus can methylate a broad range of aromatic mono- and dicarboxylic acids in good to excellent conversions. The enzyme shows high regioselectivity on its natural substrate fumaryl-l-tyrosine, trans, trans-muconic acid and a number of the dicarboxylic acids tested. Dicarboxylic acids are generally better substrates than monocarboxylic acids, although some substituents are able to compensate for the absence of a second acid group. For dicarboxylic acids, the second methylation shows strong pH dependency with an optimum at pH 5.5–6. Potential for application in industrial biotechnology was demonstrated in a cascade for the production of a bioplastics precursor (FDME) from bioderived 5-hydroxymethylfurfural (HMF).

PROCESS FOR PRODUCING 2,5-FURANDICARBOXYLIC ACID FROM ETHERS OF 5-HYDROXYMETHYLFURFURAL

Process for producing a carboxylic acid composition comprising 2,5-furandicarboxylic acid, comprising the steps: a) oxidizing an oxidizable compound comprising 5-alkoxymethylfurfural in an oxidation reactor in the presence of a saturated organic acid solvent having from 2 to 6 carbon atoms and a catalyst system comprising cobalt, manganese and bromine using an oxidizing gas at a temperature in the range of 160 to 210 °C to obtain a crude carboxylic acid composition comprising mono alkyl ester of 2,5-furandicarboxylic acid and solid 2,5- furandicarboxylic acid, b) isolating at least a portion of the solid 2,5-furandicarboxylic acid from the crude carboxylic acid composition in a solid-liquid separation zone to generate a solid cake and a mother liquor, c) determining the amount of manganese and/or cobalt in the cake, and d) increasing the amount of one or more controlling acids in the oxidation reactor, if the determined amount of manganese and/or cobalt in the cake exceeds a predefined threshold value, wherein the one or more controlling acids are selected from the group consisting of hydrobromic acid and mono- or dicarboxylic acids having from 2 to 5 carbon atoms and a pKa of less than 3.2, wherein the mother liquor comprises mono alkyl ester of 2,5-furandicarboxylic acid in the range of 0.5 to 7 % by weight with respect to the weight of the mother liquor.

NOVEL ESTERIFICATION CATALYST AND USES THEREOF

Tin (II) glucarate is found to be effective alone and in combination with other tin compounds for catalyzing the reaction of carboxylic acids such as furan-2,5-dicarboxylic acid, terephthalic acid and adipic acid with alcohols such as the C1-C3 alcohols.