66095-81-6

Basic information

• Product Name: 2-[(2-methoxy-4-nitrophenyl)amino]ethanol
• Synonyms: 2-[(2-methoxy-4-nitrophenyl)amino]ethanol;2-HYDROXYETHYLAMINO-5-NITROANISOLE
• CAS NO: 66095-81-6
• Molecular Formula: C9H12N2O4
• Molecular Weight: 212.20258
• EINECS: 266-138-0
• Mol File: 66095-81-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 87-88 °C
• Boiling Point: 406.5°C at 760 mmHg
• Flash Point: 199.6°C
• Appearance: /
• Density: 1.336g/cm³
• Vapor Pressure: 2.45E-07mmHg at 25°C
• Refractive Index: 1.612
• PKA: 14.54±0.10(Predicted)
• CAS DataBase Reference: 2-[(2-methoxy-4-nitrophenyl)amino]ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(2-methoxy-4-nitrophenyl)amino]ethanol(66095-81-6)
• EPA Substance Registry System: 2-[(2-methoxy-4-nitrophenyl)amino]ethanol(66095-81-6)

Safety Data

• Hazardous Substances Data: 66095-81-6(Hazardous Substances Data)

Usage

General Description

2-[(2-methoxy-4-nitrophenyl)amino]ethanol, also known as 4-Nitro-o-phenylenediamine, is an organic compound with the chemical formula C8H10N2O4. It is commonly used as a dye intermediate, producing a range of colors in the presence of diazonium compounds. This chemical is a white to off-white crystalline powder that is soluble in water and ethanol. It is known to have moderate acute toxicity and should be handled with care. 2-[(2-methoxy-4-nitrophenyl)amino]ethanol is also used in some industrial applications, such as in the production of hair dye and colorant products.

InChI:InChI=1/C9H12N2O4/c1-15-9-6-7(11(13)14)2-3-8(9)10-4-5-12/h2-3,6,10,12H,4-5H2,1H3

Upstream product

• 540-51-2 2-bromoethanol 
• 97-52-9 2-methoxy-4-nitrophenylamine 
• 75-21-8 oxirane 

Downstream Products

• 1363648-59-2 C₂₂H₂₅N₅O₃ 
• 1363652-92-9 C₂₂H₂₅N₅O₃ 
• 1363662-62-7 C₁₅H₁₈N₄O₃ 
• 1363648-60-5 C₂₂H₂₇N₅O 
• 1363653-25-1 4-amino-2-methoxy-N-{2-[N'-(2-picolyl)-N'-(2-pyridin-2-yl)ethyl]amino}ethylaniline 
• 1363667-64-4 C₂₅H₃₆N₄O₅ 
• 1311164-59-6 C₃₇H₄₀N₆O₃ 
• 1311164-61-0 C₃₇H₄₀N₆O₃ 
• 1311164-62-1 C₃₀H₃₃N₅O₃ 
• 1363666-45-8 C₂₅H₃₄N₄O₇ 
• 86771-81-5 N-(2-bromoethyl)-2-methoxy-4-nitroaniline 

Relevant articles and documents

Two-photon probes for Zn2+ ions with various dissociation constants. Detection of Zn2+ ions in live cells and tissues by two-photon microscopy

A series of Zn2+-selective two-photon fluorescent probes (AZnM1-AZnN) that had a wide range of dissociation constants (Kd TP=8 nm-12 νM) were synthesized. These probes showed appreciable water solubility (>3 νM), cell permeability, high photostability, pH insensitivity at pH>7, significant two-photon action cross-sections (86-110 GM) upon complexation with Zn2+, and can detect the Zn2+ ions in HeLa cells and in living tissue slices of rat hippocampal at a depth of >80 νm without mistargeting and photobleaching problems. These probes can potentially find application in the detection of various amounts of Zn 2+ ions in live cells and intact tissues. A-tissue a-tissue, we all fall down: A series of Zn2+-ion selective two-photon fluorescent probes with a wide range of dissociation constants (KdTP=8 nM-12 νM) were developed to be able to detect the Zn2+ ions in live cells and intact tissues at a depth of>80 νm without the drawbacks of mistargeting and photobleaching.

Cytotoxic compounds. Part 21. Chloro-, methoxy-, and methoxy-carbonyl-derivatives of (bis-2-chloroethylamino)-phenols and -anilines

New or improved syntheses are described of some NN-bis-2-chloroethylanilines carrying both a free phenolic group and a methoxycarbonyl ring substituent. A study has been made of the hydroxyethylation, with ethylene oxide, of a variety of chloro-, methoxy-, and methoxycarbonyl-nitroanilines, and of methoxy- and methoxycarbonyl-N-acylphenylenediamines. Bishydroxyethylation was inhibited by an o-methoxycarbonyl group and by an o- or p-nitro-group, but otherwise the NN-bis-2-hydroxyethyl derivatives were obtained and subsequently converted into the NN-bis-2-chloroethyl compounds. Reduction of the nitro-group, or hydrolysis of the acylamino-group, in these dichlorides led to NN-bis-2-chloroethylanilines carrying both a free amino-group and also a methoxycarbonyl-, methoxy-, or chloro-group as ring substituents. The ring-substituted (bis-2-chloroethylamino)-phenols or -anilines are precursors of mustard urethanes having potential importance as anti-tumour agents.