66-28-4 Usage
Description
Strophanthidin, a naturally occurring cardiac glycoside, is derived from the seeds of the Strophanthus plant. It possesses potent inotropic and chronotropic effects on the heart, making it a significant compound in the field of cardiology. Its unique structure allows it to bind to and inhibit the Na+/K+ ATPase pump, leading to increased intracellular calcium levels and enhanced myocardial contractility.
Uses
Used in Pharmaceutical Industry:
Strophanthidin is used as a cardiotonic agent for the treatment of heart failure and certain arrhythmias. Its ability to strengthen myocardial contractions and regulate heart rate makes it a valuable therapeutic option for patients with compromised cardiac function.
Used in Research Applications:
Strophanthidin is utilized in scientific research to study the effects of cardiac glycosides on neurotransmitter release and other physiological processes. For instance, the synthesis of acetylstrophanthidin and its impact on neurotransmitter release from dog saphenous vein has been investigated, providing insights into the mechanisms of action and potential applications of these compounds in medicine.
Biochem/physiol Actions
Strophanthidin is a cardiotonic steroid that elevates the activity of Na+/K+-ATPase in cardiac myocytes.1 It decreases the potassium content and raises the sodium content in rabbit renal cortex slices.2
Check Digit Verification of cas no
The CAS Registry Mumber 66-28-4 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 6 and 6 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 66-28:
(4*6)+(3*6)+(2*2)+(1*8)=54
54 % 10 = 4
So 66-28-4 is a valid CAS Registry Number.
InChI:InChI=1/C23H32O6/c1-20-6-3-17-18(4-8-22(27)11-15(25)2-7-21(17,22)13-24)23(20,28)9-5-16(20)14-10-19(26)29-12-14/h10,13,15-18,25,27-28H,2-9,11-12H2,1H3/t15-,16?,17?,18?,20+,21-,22-,23-/m0/s1
66-28-4Relevant articles and documents
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Kreis et al.
, p. 593,598 Anm.22 (1957)
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THERMAL TRANSFORMATION OF CARDIAC GLYCOSIDES II. ACIDLESS HYDROLYSIS OF LABILE GLYCOSIDES IN AQUEOUS ALCOHOLIC SOLUTIONS AND PROSPECTS FOR ITS UTILIZATION
Makarevich, I. F.,Tishchenko, A. A.,Terno, I. S.
, p. 53 - 55 (2007/10/02)
The thermal transformations of cardiac glycosides in neutral alcoholic solutions have been investigated.The kinetics of their acidless hydrolysis at 100 and 142 deg C and the activation energy of the process have been studied.The possibility has been shown of the stepwise hydrolysis of natural trisdigitoxosides with the production of difficulty available mono- and bisdigitoxosides.The following were used as the objects of investigation: convallatoxin, glucostrophanthidin, cheirotoxin, desglucocheirotoxin, erycordin, erysimin, erysimoside, digitoxin, and cymarin.
NEOCONVALLOSIDE - A CARDENOLIDE GLYCOSIDE FROM PLANTS OF THE GENUS Convallaria
Komissarenko, N. F.,Stupakova, E. P.
, p. 186 - 189 (2007/10/02)
In a study of the epigeal part and seeds of Convallaria keiskei, C. majalis, and C. transcaucasica, in addition to lokundjoside, convalloside, convallotoxoloside, and neovallotoxoloside, we have isolated the previously unknown glycoside neoconvalloside, for which, on the basis of the physicochemical properties of the compound and of the products of its chemical transformations, the structure of strophanthidin 3-O- 2)-α-L-rhamnopyranoside> has been esteblished.
Active principles of Cheiranthus cheiri L..
SCHINDLER
, p. 512 - 514 (2007/10/07)
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