658-27-5

Basic information

• Product Name: (3-FLUOROPHENYL)HYDRAZINE
• Synonyms: (3-FLUOROPHENYL)HYDRAZINE;AKOS BBS-00006970;1-(3-Fluorophenyl)hydrazine
• CAS NO: 658-27-5
• Molecular Formula: C₆H₇FN₂
• Molecular Weight: 126.13
• Mol File: 658-27-5.mol
• Article Data: 9

Chemical Properties

• Melting Point: 28 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 88 °C(Press: 2 Torr)
• Appearance: /
• Density: 1.257±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 5.06±0.10(Predicted)
• CAS DataBase Reference: (3-FLUOROPHENYL)HYDRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: (3-FLUOROPHENYL)HYDRAZINE(658-27-5)
• EPA Substance Registry System: (3-FLUOROPHENYL)HYDRAZINE(658-27-5)

Safety Data

• Hazardous Substances Data: 658-27-5(Hazardous Substances Data)

Usage

Description

(3-FLUOROPHENYL)HYDRAZINE, also known as (3-Fluorophenyl)hydrazine, is a hydrazine derivative with the chemical formula C6H5FN2. It features a fluorine atom attached to a phenyl ring, which contributes to its unique chemical properties and reactivity.

Uses

Used in Pharmaceutical Industry:
(3-FLUOROPHENYL)HYDRAZINE is used as a building block for the synthesis of various pharmaceutical compounds, playing a crucial role in the development of new drugs.
Used in Organic Synthesis:
(3-FLUOROPHENYL)HYDRAZINE is used as a reagent in the preparation of other organic compounds, particularly through its ability to react with carbonyl compounds to form hydrazones, which are valuable intermediates in organic chemistry.
Used in Agrochemicals:
(3-FLUOROPHENYL)HYDRAZINE has potential applications in the field of agrochemicals, where it may be utilized in the development of new pesticides or other agricultural chemicals.
Used as a Precursor for Biologically Active Molecules:
(3-FLUOROPHENYL)HYDRAZINE can be used as a precursor for the synthesis of various biologically active molecules, contributing to the advancement of medical and biological research.
It is important to handle (3-FLUOROPHENYL)HYDRAZINE with care, as it is toxic and can cause irritation to the skin, eyes, and respiratory system. Proper safety measures should be taken during its use and manipulation.

Upstream product

• 1073-06-9 3-fluorobromobenzene 
• 372-19-0 meta-fluoroaniline 

Downstream Products

• 620619-33-2 C₁₀H₅Cl₂FN₂O 
• 1416983-50-0 C₁₃H₁₃FN₂O₂S 
• 1456790-23-0 5-[5-amino-1-(3′-fluorophenyl)-1H-pyrazole-4-yl]-1H-tetrazole 
• 1431629-35-4 C₁₄H₁₁FN₂ 
• 81761-79-7 1-(3-Fluoro-phenyl)-4-methyl-5,5-dioxo-4,5-dihydro-1H-5λ⁶-thia-1,2,4-triaza-cyclopenta[a]naphthalene-3-carboxylic acid methyl ester 
• 1426397-21-8 C₂₃H₁₈FN₅O₃S 
• 1426397-20-7 1-(3-fluorophenyl)-4-methyl-N-(4-nitrophenyl)-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxamide 5,5-dioxide 
• 1426397-19-4 C₂₄H₁₉FN₄O₆S₂ 
• 1426397-09-2 C₂₄H₂₀FN₅O₅S₂ 
• 1426397-03-6 1-(3-fluorophenyl)-4-methyl-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxylic acid 5,5-dioxide 
• 1431139-78-4 C₂₆H₂₃Cl₂FN₆O₂ 
• 1226167-76-5 C₁₁H₉FN₂O₂ 
• 1344661-39-7 C₁₃H₁₃FN₂O₂ 
• 1418202-46-6 2-(3-fluorophenyl)-1,2-dihydrophthalazine 

Relevant articles and documents

Fluorine-substituted phenyl pyrazole amide derivative, and preparation method and application thereof

The invention relates to a fluorine-substituted phenyl pyrazole amide derivative with insecticidal activity as shown in a general formula (I), and a preparation method and application thereof. On the basis of an existing phenyl pyrazole amide compound, fl

Preparation method for 3-fluorophenylhydrazine hydrochloride

The invention relates to a preparation method for 3-fluorophenylhydrazine hydrochloride. The preparation method comprises the following steps: diazotization, reduction, purification and salt formation. During diazotization and reduction, concentrated hydrochloric acid enables a reaction solution to maintain highly acidic, so smooth and complete reaction is guaranteed. In the step of reduction, zinc dust-concentrated hydrochloric acid is used as a reducing agent to replace sodium hyposulfite, sodium bisulfate, stannous chloride-hydrochloric acid, etc., and the zinc dust-concentrated hydrochloric acid is good in reducing property and high in yield, shortens reaction time, enables impurities like zinc hydroxide produced after the reaction to be easy to remove and allows produced 3-fluorophenylhydrazine hydrochloride to be low in impurity content and high in purity. In the step of salt formation, acetone is used for leaching, so product purity is improved and product appearance is guaranteed. The preparation method is stable and reliable in process and easy to operate; and produced 3-fluorophenylhydrazine hydrochloride is high in purity (no less than 99% according to the results of content measurement via high performance liquid chromatography), has a yield of no less than 39% and completely meets market demands for 3-fluorophenylhydrazine hydrochloride.

Synthesis and biological evaluation of 4-(2-fluorophenoxy)-3,3′-bipyridine derivatives as potential c-met inhibitors

Six series of novel 4-(2-fluorophenoxy)-3,3′-bipyridine derivatives conjugated with aza-aryl formamide/amine scaffords were designed and synthesized through a structure-based molecular hybridization approach. The target compounds were evaluated for c-Met kinase inhibitory activities and cytotoxicity against four cancer cell lines (HT-29, A549, MKN-45 and MDA-MB-231) in vitro. Most compounds exhibited moderate to excellent potency, and the most promising candidate 26c (c-Met kinase IC50 = 8.2 nM) showed a 4.7-fold increase in cytotoxicity against c-Met-addicted MKN-45 cell line in vitro (IC50 = 3 nM), superior to that of Foretinib (IC50 = 23 nM). The preliminary structure-activity relationship indicated that a 1H-benzo [e] [1,3,4]thiadiazine-3-carboxamide-4,4-dioxide moiety as linker contributed to the antitumor potency.