65417-22-3

Basic information

• Product Name: Methyl2-Methyl-1H-indole-3-carboxylate
• Synonyms: Methyl2-Methyl-1H-indole-3-carboxylate;2-Methyl-3-methoxycarbonylindole
• CAS NO: 65417-22-3
• Molecular Formula: C₁₁H₁₁NO₂
• Molecular Weight: 189.21054
• Mol File: 65417-22-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 165 °C
• Boiling Point: 331.7±22.0 °C(Predicted)
• Appearance: /
• Density: 1.212±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 15.99±0.30(Predicted)
• CAS DataBase Reference: Methyl2-Methyl-1H-indole-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl2-Methyl-1H-indole-3-carboxylate(65417-22-3)
• EPA Substance Registry System: Methyl2-Methyl-1H-indole-3-carboxylate(65417-22-3)

Safety Data

• Hazardous Substances Data: 65417-22-3(Hazardous Substances Data)

Usage

General Description

Methyl 2-methyl-1H-indole-3-carboxylate is a chemical compound with the molecular formula C12H11NO2. It is a derivative of indole, a heterocyclic aromatic organic compound. Methyl2-Methyl-1H-indole-3-carboxylate is commonly used in the pharmaceutical industry as an intermediate in the synthesis of various pharmaceuticals and fine chemicals. It is a white to beige crystalline powder with a melting point of around 78-80°C. Methyl 2-methyl-1H-indole-3-carboxylate is known for its potential biological activities and is often used as a building block in the production of complex organic molecules for medicinal and research purposes.

Upstream product

• 5747-06-8 4-phenylpent-4-enoic acid 
• 65417-20-1 methyl 2-methylquinoline-4-carboxylate 1-oxide 
• 75-65-0 tert-butyl alcohol 

Downstream Products

• 154953-37-4 methyl 2-methyl-1-phenylsulphonylindole-3-carboxylate 
• 1450658-32-8 methyl 2-methyl-1-phenyl-1H-indole-3-carboxylate 
• 1450658-24-8 methyl 1-benzyl-2-methyl-1H-indole-3-carboxylate 
• 1450658-33-9 2-methyl-1-phenyl-1H-indole-3-carboxylic caid 
• 1450651-79-2 N-((2-hydroxy-4,6-dimethylpyridin-3-yl)methyl)-2-methyl-1-phenyl-1H-indole-3-carboxamide 
• 1450651-48-5 1-benzyl-N-((2-hydroxy-4,6-dimethylpyridin-3-yl)methyl)-2-methyl-1H-indole-3-carboxamide 
• 885525-21-3 1-benzyl-2-methyl-1H-indole-3-carboxylic acid 
• 154953-45-4 methyl 2-bromomethyl-1-phenylsulphonylindole-3-carboxylate 

Relevant articles and documents

Rhodium(III)-Catalyzed Synthesis of Cinnolinium Salts from Azobenzenes and Diazo Compounds

A Rh(III)-catalyzed C?H activation of azobenzenes in the coupling with diazo compounds has been realized, providing a straightforward strategy to access functionalized cinnolinium triflates in high yields. This protocol features silver free mild reaction conditions and compatibility with diverse functional groups. The coupling proceeds via initial Rh(III)-catalyzed C?H alkylation, followed by zinc triflate-mediated cyclization, where zinc triflate acts as a Lewis acid as well as a triflate source. (Figure presented.).

Studies on the N-Oxides of ?-Deficient N-Heteroaromatics. XXXVI. Photochemical and Thermal Michael Reactions of Alcohols with Methyl 2-Phenyl-3,1-benzoxazepine-5-carboxylate and Its Derivatives

Irradiation (>/=300 nm) of methyl 2-phenyl-3,1-benzoxazepine-5-carboxylate in an alcohol afforded the Z-isomer of methyl 3-alkoxy-2-(2-benzamidophenyl)-acrylate as the major product.In contrast, thermal reaction of the oxazepine with a primary alcohol in