6530-09-2

Basic information

• Product Name: 3-Aminoquinuclidine dihydrochloride
• Synonyms: LABOTEST-BB LT00012585;3-AMINOQUINUCLIDINE DIHYDROCHLORIDE;3-AMINO-1-AZABICYCLO[2.2.2]OCTANE DIHYDROCHLORIDE;3-AMINOCHINUCLIDIN DIHYDROCHLORIDE;QUINUCLIDIN-3-AMINE DIHYDROCHLORIDE;TIMTEC-BB SBB000378;1-Azabicyclo[2.2.2]octan-3-amine, Dihydrochloride;3-Aminoquiuclidine diHCl
• CAS NO: 6530-09-2
• Molecular Formula: C₇H₁₄N₂*2ClH
• Molecular Weight: 199.12
• EINECS: 229-424-6
• Product Categories: Amines;Ring Systems;Building Blocks;Heterocyclic Building Blocks;Quinuclidines;Heterocycles;Intermediates
• Mol File: 6530-09-2.mol
• Article Data: 10

Chemical Properties

• Melting Point: 321-323 °C (dec.)(lit.)
• Boiling Point: 165.9 °C at 760 mmHg
• Flash Point: 51.1 °C
• Appearance: White to almost white/Powder
• Density: 1.06 g/cm3
• Vapor Pressure: 1.83mmHg at 25°C
• Storage Temp.: Refrigerator
• Solubility: Methanol, Water
• CAS DataBase Reference: 3-Aminoquinuclidine dihydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Aminoquinuclidine dihydrochloride(6530-09-2)
• EPA Substance Registry System: 3-Aminoquinuclidine dihydrochloride(6530-09-2)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 36/37/38-22
• Safety Statements: 22-24/25
• WGK Germany: 3
• RTECS: VD4590000
• Hazardous Substances Data: 6530-09-2(Hazardous Substances Data)

Usage

Chemical Properties

white to almost white powder

Uses

An intermediate in the preparation of Azasetron.

InChI:InChI:1S/C7H14N2.2ClH/c8-7-5-9-3-1-6(7)2-4-9;;/h6-7H,1-5,8H2;2*1H

Upstream product

• 142999-60-8 (3S)-3-<(R)-(1-phenyl)ethylamino>-quinuclidine 
• 120577-33-5 (3R)-3-<(S)-(1-phenyl)ethylamino>-quinuclidine 
• 134932-30-2 R-N-(Quinuclidinyl-3)-propionamide 
• 120570-06-1 N-((S)-1-phenylethyl)-3-quinuclidinimine 
• 1193-65-3 3-quinuclidinone hydrochloride 
• 3731-38-2 3-Quinuclidinone 
• 120570-09-4 (3R)-3-<(S)-(1-phenyl)ethylamino>-quinuclidine dihydrochloride 
• 134932-29-9 S-N-(quinuclidinyl-3)-propionamide 
• 1619-34-7 3-quinuclidinol 
• 25333-42-0 (R)-quinuclidin-3-ol 
• 59653-40-6 (+)-Aceclidine 
• 120570-06-1 N-((R)-1-phenylethyl)-3-quinuclidinimine 
• 120570-09-4 (3S)-3-<(R)-(1-phenyl)ethylamino>-quinuclidine dihydrochloride 
• 142999-65-3 N-<(3S)-3-quinuclidinyl> phthalimide 

Downstream Products

• 355385-47-6 (R)-N-(1-Azabicyclo[2.2.2]oct-3-yl)(5-(4-chlorophenyl)furan-2-carboxamide) 
• 355386-91-3 (R)-N-(1-azabicyclo[2.2.2]oct-3-yl)(5-bromothiophene-3-carboxamide) 
• 478169-50-5 N-((3R)-1-azabicyclo[2.2.2]oct-3-yl)-1,3-benzodioxole-5-carboxamide 4-methylbenzenesulfonate 

Relevant articles and documents

Kinetic Self-Sorting of Dynamic Covalent Catalysts with Systemic Feedback Regulation

Constructing small molecule systems that mimic the functionality exhibited in biological reaction networks is a key objective of systems chemistry. Herein, we report the development of a dynamic catalytic system where the catalyst activity is modulated through a dynamic covalent bond. By connecting a thermodynamically controlled rearrangement process to resolution under kinetic control, the catalyst system underwent kinetic self-sorting, resulting in amplification of a more reactive catalyst while establishing a catalytic feedback mechanism. The dynamic catalyst system furthermore responded to catalytic events by self-perturbation to regulate its own activity, which in the case of upregulation gave rise to systemic autocatalytic behavior.

Improved preparation of (R) and (S)-3-aminoquinuclidine dihydrochloride

An improved procedure for the synthesis of either (R) or (S)-3-aminoquinuclidine was developed. Key intermediate imine 2 was made in a one pot process using lithium oxide as the base and molecular sieves.

Indole derivatives and drugs

The object of the invention is to provide a novel compound having serotonin antagonist activity. The invention is directed to an indolecarboxamide derivative of the following general formula [I] and a serotonin antagonist composition comprising the same derivative as an active ingredient. STR1 (wherein R1 is a lower alkyl and R2 is hydrogen, a halogen, a lower alkyl or a lower alkoxy.) The compound of the invention is effective as a gastrointestinal motor activity regulator, antimigraine, antipsychotic or antianxiety drug. The compound is also effective as a therapeutic drug for dementia or orthostatic hypotension.