65294-33-9Relevant articles and documents
Glutathione Responsive β-Cyclodextrin Conjugated S-Nitrothiols as a Carrier for Intracellular Delivery of Nitric Oxide
Jia, Fan,Deng, Yongyan,Fang, Yu,Jin, Qiao,Ji, Jian
, p. 583 - 591 (2019)
Nitric oxide (NO) exerts multiple functions in many life processes and was of great significance in a variety of biomedical scenarios. However, the mismatches between releasing locations and NO active sites seriously limited the available NO at areas of i
A oleanolic acid with amine cyclodextrin clathrate
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Paragraph 0051-0052, (2017/12/02)
The invention discloses a clathrate compound of pentacyclic triterpene oleanolic acid and amine cyclodextrin, the amine cyclodextrin is amino-substituted beta-cyclodextrin, The clathrate compound is prepared by employing a solvent method or an ultrasonic method; after oleanolic acid and amine cyclodextrin form the clathrate, the solubility of clathrate in water can be greatly increased, stability is increased, and bioavailability is increased. The antitumor in-vitro experiment shows that the clathrate has good antitumor in-vitro activity; the preparation method has the advantages of simple process, easy operation and mild reaction condition, and can be used for development of new oleanolic acid preparation.
Merging supramolecular catalysis and aminocatalysis: Amino-appended β-cyclodextrins (ACDs) as efficient and recyclable supramolecular catalysts for the synthesis of tetraketones
Ren, Yufeng,Yang, Bo,Liao, Xiali
, p. 22034 - 22042 (2016/03/08)
Well-designed amino-appended β-cyclodextrins (ACDs) with an amino side chain of different lengths at the primary face of β-CD were synthesized and employed in the catalytic synthesis of a series of tetraketones as supramolecular catalysts in water for the first time. Yields of 58-97% were obtained with up to 30 examples of substrate. The catalyst could be recycled easily, while a 92% yield and 84% rate of catalyst recovery could be achieved after 8 cycles of catalyst recycling. Moreover, a catalytic mechanism merging supramolecular catalysis and aminocatalysis could be proposed through detailed 1D and 2D NMR, ESI-MS and Job plot analyses. This protocol retained the promising characteristics of ambient temperature, green medium, simple operation, broad substrate scope, excellent yields, superb catalyst recycling performance and unique catalytic mechanism.