65202-58-6

Basic information

• Product Name: 3-bromo-6-methylpyridazine
• Synonyms: 3-bromo-6-methylpyridazine;Pyridazine, 3-broMo-6-Methyl-;6-Methyl-3-broMopyridazine
• CAS NO: 65202-58-6
• Molecular Formula: C₅H₅BrN₂
• Molecular Weight: 173.012
• Mol File: 65202-58-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 285.041 °C at 760 mmHg
• Flash Point: 126.188 °C
• Appearance: /
• Density: 1.597 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 1.26±0.10(Predicted)
• CAS DataBase Reference: 3-bromo-6-methylpyridazine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-bromo-6-methylpyridazine(65202-58-6)
• EPA Substance Registry System: 3-bromo-6-methylpyridazine(65202-58-6)

Safety Data

• Hazardous Substances Data: 65202-58-6(Hazardous Substances Data)

Usage

Description

3-Bromo-6-methylpyridazine is an organic compound belonging to the pyridazine family, characterized by a fused six-membered nitrogen-containing ring structure. It has a bromine atom at the 3rd position and a methyl group at the 6th position, which contributes to its chemical properties and reactivity.

Uses

Used in Pharmaceutical Industry:
3-Bromo-6-methylpyridazine is used as a reagent for the synthesis of piperazinyl quinolines, which serve as chemosensitizers to increase the susceptibility of Candida albicans to fluconazole. This application aids in the development of more effective antifungal treatments.
Used in Central Nervous System (CNS) Therapeutics:
3-Bromo-6-methylpyridazine is also utilized in the preparation of cyclohexyl fluoropyrimidinyl benzamides, which are CNS penetrable P2X7 receptor antagonists. These compounds have potential therapeutic applications in the treatment of various neurological disorders and conditions related to the central nervous system.

Upstream product

• 5157-08-4 3-methyl-4,5-dihydro-6-oxopyridazine 
• 539-88-8 4-oxopentanoic acid ethyl ester 
• 13327-27-0 6-Methylpyridazin-3(2H)-on 
• 157200-06-1 Trifluoromethanesulfonic acid 6-methylpyridazine-3-yl ester 
• 94248-99-4 6-methyl-2H-pyridazin-3-one; hydrobromide 

Downstream Products

• 916248-39-0 3-bromo-6-(bromomethyl)pyridazine 
• 38956-79-5 3-hydrazinyl-6-methylpyridazine 

Relevant articles and documents

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