65036-57-9

Basic information

• Product Name: 1,4-dichloro-2,3-dinitrobenzene
• Synonyms: 1,4-dichloro-2,3-dinitrobenzene
• CAS NO: 65036-57-9
• Molecular Weight: 236.999
• EINECS: -0
• Mol File: 65036-57-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1,4-dichloro-2,3-dinitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-dichloro-2,3-dinitrobenzene(65036-57-9)
• EPA Substance Registry System: 1,4-dichloro-2,3-dinitrobenzene(65036-57-9)

Safety Data

• Hazardous Substances Data: 65036-57-9(Hazardous Substances Data)

Usage

Physical state at room temperature

Yellow solid

Uses

a. Precursor for dyes
b. Agricultural chemicals
c. Pharmaceuticals
d. Manufacturing of other organic compounds
e. Reagent in organic synthesis

Toxicity

Toxic

Harmful effects

a. If swallowed
b. If inhaled
c. If absorbed through the skin

Known irritant

a. To the skin
b. To the eyes
c. To the respiratory system

Regulatory status

Tightly regulated in many countries due to potential environmental and health risks

Upstream product

• 106-46-7 para-dichlorobenzene 
• 89-61-2 2,5-dichloronitrobenzene 
• 71-43-2 benzene 

Downstream Products

• 634-66-2 1,2,3,4,-tetrachlorobenzene 
• 94544-96-4 5,8-dichloro-2,3-diphenyl-quinoxaline 
• 15944-74-8 3,6-dichloro-2-nitro-aniline 
• 67382-06-3 2,3-dinitro-p-phenylenediamine 
• 720681-29-8 4-chloro-N,N-dimethyl-2,3-dinitro-aniline 
• 21732-93-4 3,6-dichloro-1,2-phenylenediamine 
• 860734-47-0 3,6-dichloro-2-nitro-anisole 

Relevant articles and documents

HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF

Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and metabolic disorders, including, but not limited to, e.g., neurological disorders, psychosis, schizophrenia, obesity, and diabetes

Improved method for preparing 1-amino-3,7,8-trichlorodibenzo-p-dioxin

An improved method was proposed for preparing 1-amino-3,7,8-trichlorodibenzo-p-dioxin.

Potent Quinoxaline-Spaced Phosphono α-Amino Acids of the AP-6 Type as Competitive NMDA Antagonists: Synthesis and Biological Evaluation

A series of α-amino-3-(phosphonoalkyl)-2-quinoxalinepropanoic acids was synthesized and evaluated for NMDA receptor affinity using a CPP binding assay.Functional antagonism of the NMDA receptor complex was evaluated in vitro using a stimulated TCP binding assay and in vivo by empolying an NMDA-induced seizure model.Some analogues also were evaluated in the -glycine binding assay.Several compounds of the AP-6 type show potent and selective NMDA antagonistic activity both in vitro and in vivo.In particular α-amino-7-chloro-3-(phosphonomethyl)-2-quinoxalinepropanoic acid (1) d isplayed an ED50 of 1.1 mg/kg ip in the NMDA lethality model.Noteworthy is α-amino-6,7-dichloro-3-(phosphonomethyl)-2-quinoxalinepropanoic acid (3) with a unique dual activity, displaying in the NMDA receptor binding assay an IC50 of 3.4 nM and in the glycine binding assay an IC50 of 0.61 μM.