64706-54-3

Basic information

• Product Name: BEPRIDIL
• Synonyms: 1-pyrrolidineethanamine,beta-((2-methylpropoxy)methyl)-n-phenyl-n-(phenylmethy;BEPRIDIL;Bepridil hydrochloride monohydrate/bepridil;1-[2-(N-Benzylanilino)-1-(isobutoxymethyl)ethyl]pyrrolidine;Bepadin;CERM-1978;Vascor;ORG-5730
• CAS NO: 64706-54-3
• Molecular Formula: C24H34N2O
• Molecular Weight: 366.54
• EINECS: 256-384-7
• Product Categories: Active Pharmaceutical Ingredients
• Mol File: 64706-54-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: bp0.1 184°; bp0.5 192°
• Flash Point: 133.2 °C
• Appearance: /
• Density: 1.0392 (rough estimate)
• Vapor Pressure: 7.77E-10mmHg at 25°C
• Refractive Index: nD20 1.5538
• Storage Temp.: 2-8°C
• PKA: 9.21±0.20(Predicted)
• Water Solubility: 7.43g/L(37 oC)
• CAS DataBase Reference: BEPRIDIL(CAS DataBase Reference)
• NIST Chemistry Reference: BEPRIDIL(64706-54-3)
• EPA Substance Registry System: BEPRIDIL(64706-54-3)

Safety Data

• Hazardous Substances Data: 64706-54-3(Hazardous Substances Data)

Usage

Description

Bepridil, also known as Tertiapin, is a tertiary amine with substituents on nitrogen being benzyl, phenyl, and 3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl. It is a pharmaceutical compound with various applications in the medical and biological fields.

Uses

Used in Antiviral Applications:
Bepridil is used as an antiviral agent for protection against the Ebola virus. Its antiviral properties make it a valuable compound in the development of treatments for viral infections.
Used in Biological Studies:
In the field of biological research, Bepridil is utilized in the study of the shortening of the electromechanical window in ketamine/xylazine-anesthetized guinea pig models. This application helps improve QTc interval prolongation and assess pro-arrhythmic risk during the early stages of drug development.
Used in Drug Development:
Bepridil is also employed in the therapeutic use of novel high/low solubility classification methods for new molecular entities. This application aids in the development and classification of new drugs, contributing to advancements in the pharmaceutical industry.

Enzyme inhibitor

This substituted pyrrolidine (FWfree-base = 366.55 g/mol) is a calcium channel blocker that inhibits the Na+ /Ca2+ exchange, exhibiting antiarrhythmic, antianginal, and vasodilatory properties. Bepridil inhibits the growth of certain brain tumors in vitro. Bepridil also binds to troponin C. Target(s): Ca2+ channels; ATP-sensitive K+ channels; Na+ -activated K+ channels.

InChI:InChI=1/C24H34N2O/c1-21(2)19-27-20-24(25-15-9-10-16-25)18-26(23-13-7-4-8-14-23)17-22-11-5-3-6-12-22/h3-8,11-14,21,24H,9-10,15-20H2,1-2H3

Relevant articles and documents

THERAPY FOR COMPLICATIONS OF DIABETES

A method for enhancing glycemic control and/or insulin sensitivity in a human subject having diabetic nephropathy and/or metabolic syndrome comprises administering to the subject a selective endothelin A (ETA) receptor antagonist in a glycemic control and/or insulin sensitivity enhancing effective amount. A method for treating a complex of comorbidities in an elderly diabetic human subject comprises administering to the subject a selective ETA receptor antagonist in combination or as adjunctive therapy with at least one additional agent that is (i) other than a selective ETA receptor antagonist and (ii) effective in treatment of diabetes and/or at least one of said comorbidities other than hypertension. A therapeutic combination useful in such a method comprises a selective ETA receptor antagonist and at least one antidiabetic, anti-obesity or antidyslipidemic agent other than a selective ETA receptor antagonist.