64657-21-2 Usage
Description
6-Acetyl-7-deacetylforskolin is a bioactive compound derived from the medical plant Coleus forskohlii. It is a byproduct in the synthesis of 9-Deoxyforskolin (D239935) and possesses various pharmacological properties, including anticancer and glucosidase inhibition activities. As an adenylyl cyclase isoform activator, it has potential applications in the treatment of hypertension and other conditions.
Uses
Used in Pharmaceutical Industry:
6-Acetyl-7-deacetylforskolin is used as an active pharmaceutical ingredient for its anticancer properties. It has the potential to target and inhibit the growth of cancer cells, making it a promising candidate for the development of cancer therapeutics.
Used in Antihypertensive Applications:
6-Acetyl-7-deacetylforskolin is used as an antihypertensive agent due to its ability to activate adenylyl cyclase isoforms, which can help regulate blood pressure and improve cardiovascular health.
Used in Drug Discovery and Development:
6-Acetyl-7-deacetylforskolin is used as a bioactive constituent in drug discovery and development processes. Its unique properties and potential therapeutic effects make it a valuable compound for further research and the development of new medications for various diseases and conditions.
Used in Enzyme Inhibition:
6-Acetyl-7-deacetylforskolin is used as a glucosidase inhibitor, which can help regulate glucose metabolism and potentially contribute to the management of diabetes and other metabolic disorders.
Overall, 6-Acetyl-7-deacetylforskolin is a versatile bioactive compound with a range of potential applications in the pharmaceutical and medical industries, making it an important compound for ongoing research and development.
Check Digit Verification of cas no
The CAS Registry Mumber 64657-21-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,4,6,5 and 7 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 64657-21:
(7*6)+(6*4)+(5*6)+(4*5)+(3*7)+(2*2)+(1*1)=142
142 % 10 = 2
So 64657-21-2 is a valid CAS Registry Number.
InChI:InChI=1/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(28-12(2)23)17(26)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1
64657-21-2Relevant articles and documents
Regioselective acetylation of 7-deacetylforskolin with 11C-acetyl chloride
Sasaki,Furukata,Ishii,Iimori,Ikegami,Nozaki,Senda
, p. 337 - 347 (2007/10/03)
Reaction conditions were studied to control the acetylating position on 7-deacetylforskolin using [11C]acetyl chloride. In a preliminary study using non-labeled acetyl chloride, pyridine, lutidine, triethylamine, N,N-diisopropylethylamine, dimethylaminopyridine (DMAP) and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) were tested as the base in the acetylation. Pyridine was effective in selective acetylation to yield forskolin in any solvent, and DBU was effective for 1-acetyl-7-deacetylforskolin. Among toluene, dichloromethane and dichloroethane, toluene was the most suitable as the solvent for the selective acetylation of the 7-OH group to give forskolin with any base. In the selectivity of acetylation with [11C]acetyl chloride, more [11C]forskolin was obtained than [11C]1-acetyl-7-deacetylforskolin (70:30) in the presence of pyridine in toluene. [11C]1-acetyl-7-deacetylforskolin was preferentially synthesized with DBU in dichloromethane, and the ratio of [11C]1-acetyl-7-deacetylforskolin to [11C]forskolin was 98:2. For the yield of the [11C]acetylated product, DBU in dichloromethane was also suitable to obtain [11C]1-acetyl-7-deacetylforskolin. However, that of pyridine in toluene did not confer any advantages upon the yield of [11C]forskolin compared with DMAP in toluene.
IDENTITY OF COLEONOL WITH FORSKOLIN: STUCTURE REVISION OF A BASE-CATALYSED REARRANGEMENT PRODUCT
Saksena, Anil K.,Green, Michael J.,Shue, Ho-Jane,Wong, Jesse K.
, p. 551 - 554 (2007/10/02)
The identity of coleonol and forskolin is shown through structure revision of a rearrangement product isolated earlier from coleonol and is confirmed by direct comparison of authentic coleonol with forskolin 1; in addition, coleonol-B should correctly represented by structure 4.
