646-01-5

Basic information

• Product Name: 3-METHYLTHIOPROPIONIC ACID
• Synonyms: 3-(Methylsulfanyl)propanoic acid;4-Thiapentanoic acid;Propanoic acid, 3-(methylthio)-;Propionic acid, 3-(methylthio)-;3-METHYTHIOPROPIONIC ACID;3-METHYLTHIO PROPIONATE;3-METHYLTHIOPROPIONIC ACID;3-METHYLMERCAPTOPROPIONIC ACID
• CAS NO: 646-01-5
• Molecular Formula: C₄H₈O₂S
• Molecular Weight: 120.17
• EINECS: 211-460-9
• Mol File: 646-01-5.mol
• Article Data: 20

Chemical Properties

• Melting Point: 16°C
• Boiling Point: 130°C 2mm
• Flash Point: 130°C/15mm
• Appearance: /
• Density: 1.160
• Vapor Pressure: 0.00741mmHg at 25°C
• Refractive Index: 1.4884
• PKA: 4.29±0.10(Predicted)
• BRN: 1743054
• CAS DataBase Reference: 3-METHYLTHIOPROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYLTHIOPROPIONIC ACID(646-01-5)
• EPA Substance Registry System: 3-METHYLTHIOPROPIONIC ACID(646-01-5)

Safety Data

• Statements: 34
• Safety Statements: 26-36/37/39
• RIDADR: 3265
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 646-01-5(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

Definition

ChEBI: A thia fatty acid acid consisting of propionic acid with a methylthio substituent at the 3-position; an intermediate in mammalian methionine metabolism in vitro. The simplest known phytotoxin, it is a blight-inducing toxin produced by the cass va pathogen Xanthomonas campestris manihotis.

InChI:InChI=1/C4H8O2S/c1-7-3-2-4(5)6/h2-3H2,1H3,(H,5,6)/p-1

Upstream product

• 74-93-1 methylthiol 
• 107-13-1 acrylonitrile 
• 77-78-1 dimethyl sulfate 
• 107-96-0 3-mercaptopropionic acid 
• 2373-51-5 chloro-methylsulfanyl-methane 
• 54974-63-9 3-(methylthio)propionitrile 
• 590-92-1 3-Bromopropionic acid 
• 5188-07-8 sodium thiomethoxide 
• 69884-58-8 trichloromethyl peroxyl 
• 74-88-4 methyl iodide 
• 13532-18-8 methyl 3-(methylthio)propionate 
• 107-94-8 chloropropionic acid 
• 550-44-7 N-methylphthalimide 
• 7647-01-0 hydrogenchloride 

Downstream Products

• 13327-56-5 3-(methylthio)propanoic acid ethyl ester 
• 69884-58-8 CCl₃O₂^(1-) 
• 91482-17-6 dimethyl-β-propiothetin toluene-p-sulphonate 
• 1054611-55-0 C₂₉H₃₆N₄O₄S 
• 1143522-15-9 1-{4-[(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-3-methylsulfanyl-propan-1-one 
• 712270-05-8 N-(2'-anilino-4,4'-bipyridin-2-yl)-3-(methylthio)propanamide 
• 256409-22-0 4-(3-bromo phenyl amine)-6-(3-methylthio propionyl amine)-quinazoline 
• 13532-18-8 methyl 3-(methylthio)propionate 
• 4337-33-1 (2‐carboxyethyl)dimethylsulfonium chloride 
• 73595-45-6 N-(4-Methoxy-phenyl)-3-methylsulfanyl-propionamide 

Relevant articles and documents

Preparation method of (2-carboxyethyl) dimethyl sulfonium chloride

The invention belongs to the technical field of feed additives, and particularly relates to a preparation method of (2-carboxyethyl) dimethyl sulfonium chloride, which comprises the following steps: (1) dissolving 3-bromopropionic acid in an organic solvent under stirring conditions, adding sodium methyl mercaptide, carrying out heating reaction, adding water after the reaction finishes, regulating the pH value to 5-6 with hydrochloric acid, and extracting with ethyl acetate; washing an ethyl acetate layer with water after liquid separation, and carrying out rotary evaporation to remove ethylacetate and water to obtain an intermediate 3-(methylthio) propionic acid; and (2) under a stirring condition, adding the intermediate 3-(methylthio) propionic acid synthesized in the step (1) into ethyl acetate, cooling to below 2 DEG C in an ice bath, introducing chloromethane to react, carrying out suction filtration and drying after the reaction is finished to obtain a 2-(carboxyethyl) dimethyl sulfonium bromide crude product, and recrystallizing with absolute ethyl alcohol to obtain the target product (2-carboxyethyl) dimethyl sulfonium chloride. The method is environmentally friendly andeasier to operate, the yield of the synthesized (2-carboxyethyl) dimethyl sulfonium chloride is high, a foul smell pollution production process is abandoned, and the body health of production personnel is guaranteed.

New phthalimide-methionine dyad-based fluorescence probes for reactive oxygen species: Singlet oxygen, hydrogen peroxide, and hypochlorite

Different reactive oxygen species were detected by the molecular probes 1-3 that were composed of the phthalimide fluorophore as reporter and a methionine-derived thioether side-chain as receptor part. The sulfoxides that were formed as the primary oxidation products show strong fluorescence in the blue-green (430-540?nm) spectral region. Self-sensitized oxidation by singlet oxygen is in general inefficient indicating rapid electron-transfer quenching of the excited probe molecules. With hydrogen peroxide as thermal oxidant conversion to the sulfoxides is slow but can be accelerated by addition of titanium(IV) catalysts, whereas hypochlorite as oxidant behaves much more reactive even under uncatalyzed conditions. Singlet oxygen that is generated by energy transfer from the photosensitizer Rose Bengal was detected by sensor 1a with rate constants of >107M–1?s–1, a typical rate constant for the oxidation of thioethers to sulfoxides.

ONIUM SALT, LIQUID COMPOSITION CONTAINING SAID ONIUM SALT AND CELLULOSE, AND CELLULOSE RECOVERY METHOD

The invention relates to an onium salt, a liquid composition containing the onium salt and cellulose, and a method for recovering cellulose. The invention makes it possible to provide an onium salt having an extremely high ability to dissolve cellulose at temperatures of 100° C. or lower. It also makes it possible to provide a liquid composition containing this onium salt and cellulose, as a composition suitable for the recovery of cellulose, and a method for recovering cellulose efficiently by using such a liquid composition containing the onium salt and cellulose.