645-31-8

Basic information

• Product Name: Dopamine
• Synonyms: 2-benzenediol,4-(2-aminoethyl)-hydrobromide;3,4-dihydroxy-phenethylaminhydrobromide;4-(2-aminoethyl)-1,2-benzenediolhydrobromide;usafel-47;3,4-DIHYDROXY-PHENETHYLAMINE HYDROBROMIDE;3-HYDROXYTYRAMINE HYDROBROMIDE;DOPAMINE HYDROBROMIDE;4-(2-aminoethyl)pyrocatechol
• CAS NO: 645-31-8
• Molecular Formula: C8H12BrNO2
• Molecular Weight: 234.09
• EINECS: 200-110-0
• Mol File: 645-31-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 218-220 °C(lit.)
• Boiling Point: 337.7°C at 760 mmHg
• Flash Point: 158°C
• Appearance: /
• Vapor Pressure: 5.27E-05mmHg at 25°C
• CAS DataBase Reference: Dopamine(CAS DataBase Reference)
• NIST Chemistry Reference: Dopamine(645-31-8)
• EPA Substance Registry System: Dopamine(645-31-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39-37
• WGK Germany: 3
• RTECS: SH2290150
• Hazardous Substances Data: 645-31-8(Hazardous Substances Data)

Usage

Description

Dopamine, also known as 3-hydroxytyramine, is a monoamine neurotransmitter that plays a crucial role in various physiological functions, including motivation, reward, and motor control. It is derived from the amino acid tyrosine and is synthesized in the brain, where it acts as a neurotransmitter and neuromodulator.

Uses

Used in Neuroscientific Research:
Dopamine is used as a standard in the preparation of dopamine standards for measuring dopamine release and uptake in striatal brain slices from R6/1 HD model mice by fast-scan cyclic voltammetry. This helps researchers understand the role of dopamine in various neurological processes and disorders.
Used in Analytical Chemistry:
Dopamine is employed as an internal standard in the determination of catecholamines in biological tissues by liquid chromatography. This application aids in the accurate quantification of catecholamines, which are important for assessing various physiological and pathological conditions.

InChI:InChI=1/C8H11NO2.BrH/c9-4-3-6-1-2-7(10)8(11)5-6;/h1-2,5,10-11H,3-4,9H2;1H

Upstream product

• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 4230-93-7 1,2-dimethoxy-4-(2-nitro-vinyl)-benzene 
• 635-85-8 homoveratrylamine hydrochloride 
• 54373-56-7 3.4-dimethoxyphenethylamine hydrobromide 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 

Downstream Products

• 65427-91-0 6,7-dihydroxy-1-(3,4-dihydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid 
• 104822-71-1 1-(3,4-dihydroxy)phenethyl-3-carbamoylpyridinium chloride 
• 62-31-7 dopamine hydrochloride 
• 65846-04-0 N-<2-(3,4-Dihydroxyphenyl)ethyl>trifluoracetamid 
• 106005-97-4 (2E)-N-[2-(3,4-dihydroxyphenyl)ethyl]-3-(4-hydroxyphenyl)-2-propenamide 
• 1221686-11-8 BrH*C₁₆H₁₇NO₄ 
• 1221686-10-7 1-(4-methoxyphenyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline hydrobromide 
• 132257-17-1 1-(4-hydroxyphenyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline hydrobromide 
• 1221686-09-4 1-(3-nitrophenyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline hydrobromide 
• 1221686-08-3 1-(4-chlorophenyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline hydrobromide 
• 52768-23-7 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline hydrobromide 
• 1025423-92-0 1-[2-(4-chlorophenyl)ethyl]-3-[2-(3,4-dihydroxyphenyl)ethyl]thiourea 
• 90057-85-5 Bis-benzyloxycarbonyl-lysyldopamine-15-crown-5 
• 90057-83-3 Benzyloxycarbonyl-alanyldopamine-15-crown-5 

Relevant articles and documents

Synthetic method of high-purity dopamine hydrochloride

The invention provides a synthetic method of dopamine hydrochloride, and belongs to the field of drug synthesis. The preparation method comprises the following steps: taking 3,4-dimethoxyphenylethylamine as an initial raw material, firstly reacting with an acid to form a salt, re-crystallizing and refining to obtain 3,4-dimethoxyphenylethylamine salt, reacting with hydrobromic acid to remove methyl to generate dopamine hydrobromide, and finally reacting with hydrochloric acid to form a salt so as to obtain dopamine hydrochloride. The preparation method provided by the invention has the advantages of cheap and easily available initial raw materials, simple process, no high-temperature and high-pressure hydrogenation step, low cost, high purity and high yield, and is suitable for industrialproduction.

Method for efficiently preparing 5,6-dihydroxyindole (by machine translation)

The preparation method 5,6 - of the compound,dihydroxyindole comprises the following steps :(1): dissolving 3,4 - dialkoxybenzylethylamine and a catalyst in an organic solvent, in an organic solvent, carrying out reflux reaction, in the heated stirring state ;(2) and then further purifying to obtain (1)-hydroxyindole solid powder, which is suitable for industrial production, and has a high, product purity, stability, and easy long-term storage after the operation steps, are short ;(3) reaction steps, through an oxidation reaction, and then further purifying the intermediate compound I, and then purifying the compound I by the oxidizing agent, and then purifying the intermediate compound. I by using a, reducing agent, and then, purifying the intermediate compound I by the, oxidation reaction step 5,6 - and further, purifying the obtained dopamine white solid, powder . by oxidation reaction . The method comprises the following steps. (by machine translation)