64399-26-4Relevant articles and documents
Synthesis and Biological Activity of Arylcyclopentane-1-carboxylic Acids Aminoesters
Aghekyan,Mkryan,Tsatinyan,Gasparyan
, p. 1051 - 1054 (2019)
1-Arylcyclopentane-1-carboxylic acids were synthesized by alkaline hydrolysis of the corresponding nitriles. Reactions of the acid chlorides with N,N-dialkylaminoalkyl-and hetarylalkylalkanols provided new aminoester derivatives of 1-arylcyclopentane-1-carboxylic acids. Sympatholytic and adrenolytic activity of the obtained amino esters hydrochlorides was studied.
Development of a palladium-catalyzed α-arylation of cyclopropyl nitriles
McCabe Dunn, Jamie M.,Kuethe, Jeffrey T.,Orr, Robert K.,Tudge, Matthew,Campeau, Louis-Charles
supporting information, p. 6314 - 6317 (2015/02/19)
1,1-Disubstituted aryl cyclopropyl nitriles are useful moieties in biologically active compounds and provide access to a range of cyclopropyl derivatives. Herein, we describe the development of a palladium-catalyzed α-arylation of cyclopropyl, cyclobutyl, and cyclopentyl nitriles that affords these functional groups in one step from a variety of aryl bromides in good to excellent yields. Furthermore, we demonstrate the transformation of aryl cyclopropyl nitriles into aryl trifluoromethyl cyclopropanes.
Solvolysis Reactions: Relative Abilities of Cyclopentyl/Phenyl Groups To Stabilize an Electron-Deficient Carbon
Roberts, Donald D.,Arant, Mark E.
, p. 6464 - 6469 (2007/10/02)
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