64276-62-6

Basic information

• Product Name: ETHYL 4-PHENYLPYRROLE-3-CARBOXYLATE
• Synonyms: ETHYL 4-PHENYLPYRROLE-3-CARBOXYLATE;ETHYL 4-PHENYL-1H-PYRROLE-3-CARBOXYLATE;3-CARBETHOXY-4-PHENYLPYRROLE;SALOR-INT L164313-1EA
• CAS NO: 64276-62-6
• Molecular Formula: C₁₃H₁₃NO₂
• Molecular Weight: 215.25
• Mol File: 64276-62-6.mol
• Article Data: 13

Chemical Properties

• Melting Point: 126-128°C
• Boiling Point: 421.6°C at 760 mmHg
• Flash Point: 208.8°C
• Appearance: /
• Density: 1.148g/cm³
• Vapor Pressure: 2.56E-07mmHg at 25°C
• Refractive Index: 1.572
• Storage Temp.: 2-8°C
• CAS DataBase Reference: ETHYL 4-PHENYLPYRROLE-3-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 4-PHENYLPYRROLE-3-CARBOXYLATE(64276-62-6)
• EPA Substance Registry System: ETHYL 4-PHENYLPYRROLE-3-CARBOXYLATE(64276-62-6)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 64276-62-6(Hazardous Substances Data)

Usage

General Description

Ethyl 4-phenylpyrrole-3-carboxylate is a chemical compound with the molecular formula C13H13NO2. It is a ester derivative of pyrrole-3-carboxylic acid with an ethyl group attached to the nitrogen atom. ETHYL 4-PHENYLPYRROLE-3-CARBOXYLATE is commonly used in the synthesis of various pharmaceuticals and fine chemicals. It has also been studied for its potential biological activities, including its potential as an anti-inflammatory agent. Additionally, it is utilized for research purposes in the development of new drugs and as a building block in organic synthesis. Overall, ethyl 4-phenylpyrrole-3-carboxylate is a versatile and important chemical compound in the field of medicinal and organic chemistry.

InChI:InChI=1/C13H13NO2/c1-2-16-13(15)12-9-14-8-11(12)10-6-4-3-5-7-10/h3-9,14H,2H2,1H3

Upstream product

• 141-97-9 ethyl acetoacetate 
• 71333-60-3 (E)-1-Isocyano-2-phenyl-1-tosylethene 
• 79047-38-4 isocyanomethyl p-toluenesulfonate 
• 4192-77-2 ethyl cinnamate 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 10564-55-3 1-isocyanatomethanesulfonyl-4-methyl-benzene 
• 100-52-7 benzaldehyde 
• 17282-40-5 N-(ethoxycarbonylmethyl)pyridinium bromide 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 5292-53-5 diethyl benzalmalonate 
• 103-36-6 ethyl 3-phenyl-2-propenoate 

Downstream Products

• 131924-83-9 1-(2,4-Dichloro-benzyl)-4-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester 
• 132040-12-1 4-phenyl-1H-pyrrole-3-carboxylic acid 
• 191668-11-8 1-allyl-4-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester 

Relevant articles and documents

Pd(II)-Catalyzed [4 + 2] Heterocyclization Sequence for Polyheterocycle Generation

A new Pd(II)-catalyzed cascade sequence for the formation of polyheterocycles, from simple starting materials, is reported. The sequence is applicable to both indole and pyrrole substrates, and a range of substituents are tolerated. The reaction is thought to proceed by a Pd(II)-catalyzed C-H activated Heck reaction followed by a second Pd(II)-catalyzed aza-Wacker reaction with two Cu(II)-mediated Pd(0) turnovers per sequence. The sequence can be considered a formal [4 + 2] heterocyclization.

Palladium(II) Catalyzed C-H Functionalization Cascades for the Diastereoselective Synthesis of Polyheterocycles

C-H activation offers huge potential in the generation of complex structures from simple starting materials. Herein we report the development of a highly diastereoselective palladium(II) catalyzed C-H functionalization cascade to produce novel, unsaturate

Solvent-controlled switchable C-H alkenylation of 4-aryl-1H-pyrrole-3-carboxylates: Application to the total synthesis of (±)-rhazinilam

A solvent-controlled switchable C-H alkenylation of 4-aryl-1H-pyrrole-3-carboxylates via a Pd(OAc)2 catalyzed oxidative Heck reaction was first realized. The corresponding C2 and C5 alkenylation products were obtained in good yields with high regioselectivities, respectively. The selective C5-alkenylation was successfully applied to the total synthesis of (±)-rhazinilam.