64263-80-5

Basic information

• Product Name: N-tert-Butyloxycarbonyl-N-methyl-O-benzyl-L-threonine
• Synonyms: BOC-METHR(BZL)-OH;BOC-METHR(BZL)-OH CHA;BOC-N-ALPHA-METHYL-O-BENZYL-L-THREONINE;BOC-L-METHR(BZL)-OH;BOC-L-METHR(BZL)-OH CHA;BOC-O-BENZYL-N-METHYL-L-THREONINE;BOC-N-ME-THR(BZL)-OH CHA;BOC-N-ME-THREONINE(BZL)-OH CHA
• CAS NO: 64263-80-5
• Molecular Formula: C₁₇H₂₅NO₅
• Molecular Weight: 323.38
• Product Categories: Amino Acids
• Mol File: 64263-80-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 442.9±45.0 °C(Predicted)
• Appearance: /
• Density: 1.141±0.06 g/cm3(Predicted)
• Refractive Index: 1.52
• Storage Temp.: Store at RT.
• PKA: 3.52±0.10(Predicted)
• BRN: 6068811
• CAS DataBase Reference: N-tert-Butyloxycarbonyl-N-methyl-O-benzyl-L-threonine(CAS DataBase Reference)
• NIST Chemistry Reference: N-tert-Butyloxycarbonyl-N-methyl-O-benzyl-L-threonine(64263-80-5)
• EPA Substance Registry System: N-tert-Butyloxycarbonyl-N-methyl-O-benzyl-L-threonine(64263-80-5)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 64263-80-5(Hazardous Substances Data)

Usage

Chemical Properties

White powder

InChI:InChI=1/C17H25NO5/c1-12(22-11-13-9-7-6-8-10-13)14(15(19)20)18(5)16(21)23-17(2,3)4/h6-10,12,14H,11H2,1-5H3,(H,19,20)/t12?,14-/m0/s1

Upstream product

• 15260-10-3 N-Boc-O-benzyl-L-threonine 
• 74-88-4 methyl iodide 

Downstream Products

• 101759-83-5 Boc-MeThr(OBzl)-Abu-Sar-MeLeu-Val-MeLeu-Ala-OBzl 
• 223923-54-4 (2S,3R)-N-Boc-N-methyl-O-benzyl-L-threonine trimethylsilyl ester 
• 238746-24-2 2,2,2-trichloroethyl(2S,3R)-3-benzyloxy-2-butanoate 
• 238746-25-3 2,2,2-trichloroethyl(2S,3R)-3-benzyloxy-2-(N)-methylaminobutanoate 
• 238746-30-0 (2S,3R)-3-Benzyloxy-2-[((R)-4-benzyloxycarbonylamino-4-methoxycarbonyl-butyryl)-methyl-amino]-butyric acid 2,2,2-trichloro-ethyl ester 
• 223923-56-6 N-Boc-D-γ-glutamyl-(α-methyl ester)-N-methyl-O-benzyl-L-threonine trimethylsilylethyl ester 
• 223924-04-7 2-[3-(2-{[4-(3-tert-butoxycarbonylamino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoylamino)-4-methoxycarbonyl-butyryl]-methyl-amino}-3-hydroxy-butyrylamino)-3-methoxycarbonyl-2-methyl-propionylamino]-3-methyl-butyric acid 
• 223924-03-6 3-(1-allyloxycarbonyl-2-methyl-propylcarbamoyl)-2-(2-{[4-(3-tert-butoxycarbonylamino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoylamino)-4-methoxycarbonyl-butyryl]-methyl-amino}-3-hydroxy-butyrylamino)-butyric acid methyl ester 
• 1192373-28-6 C₂₃H₃₆N₂O₆ 

Relevant articles and documents

Total synthesis of proposed structure of coibamide A, a highly N- and O-methylated cytotoxic marine cyclodepsipeptide

Total synthesis of the originally proposed structure of coibamide A, a highly N- and O-methylated cytotoxic marine cyclodepsipeptide, has been accomplished by using a [(4+1)+3+3]-peptide fragment-coupling strategy and careful examination and optimization

Synthesis and Antimitogenic Activities of Four Analogues of Cyclosporin A Modified in the 1-Position

Cyclosporin A (CSA,1), an immunosuppressive cyclic undecapeptide, contains a unique N-methylated amino acid, (2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(N-methylamino)-6-octenoic acid, called both C-9-ene and MeBmt that