6398-74-9Relevant articles and documents
METHOD FOR PREPARING S-Bz-MAG3 AS A PRECURSOR OF CONTRAST MEDIA
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Paragraph 0053; 0054; 0055; 0056; 0057; 0058, (2019/04/25)
The present invention provides a method for preparing S-Bz-MAG3 as a precursor of contrast media. Thioglycolic acid and benzoyl chloride are taken for the thiol protection reaction. Next, N,N′-dicyclohexylcarbodiimide and N-hydroxysuccinimide are converte
Synthesis and biological characterization of 99mTc(I) tricarbonyl cysteine complex, a potential diagnostic for assessment of renal function
Park, Sang Hyun,Jang, Beom Su,Park, Kyung Bae
, p. 63 - 73 (2007/10/03)
Cysteine containing three functional groups, i.e. a carboxyl, sulfhydryl, and amino group, has been labelled with 99mTc(I) tricarbonyl precursor (2) in order to study the renal characteristics of the resulting 99mTc(I) tricarbonyl cy
Kinetic and structural consequences of the leaving group in substrates of a class C β-lactamase
Ahn, Yong-Mo,Pratt
, p. 1537 - 1542 (2007/10/03)
The class C β-lactamase of Enterobacter cloacae P99 is known to catalyze the hydrolysis of certain acyclic (thio)esters. Previous experiments have employed thioglycolate, m-hydroxybenzoate, and phenylphosphate leaving groups. The relative effectiveness of these leaving groups has now been quantitatively assessed by employment of a series of compounds with common acyl groups, and found to rank in the order phenylphosphate >m-hydroxybenzoate >thioglycolate. Structural models suggest that these leaving groups interact during acylation principally with Tyr 150, Lys 315, and Thr 316 of the β-lactamase active site. The positions of the leaving group carboxylates in these models is compared with those in published crystal structures of complexes of class C β-lactamases with β-lactams. The particular effectiveness of the acyl phosphate indicates the positions of two oxyanions that strongly interact with the active site. This information should be useful in the design of inhibitors of class C β-lactamases.