6373-71-3

Basic information

• Product Name: N-cyclohexyl-2-nitroaniline
• Synonyms: BAS 00341142;cyclohexyl-(2-nitrophenyl)amine;Cyclohexyl-(2-nitro-phenyl)-amine;MFCD00579685;Oprea1_490253;ST012286;ZINC04600927;N-cyclohexyl-2-nitroaniline
• CAS NO: 6373-71-3
• Molecular Formula: C₁₂H₁₆N₂O₂
• Molecular Weight: 220.27
• Mol File: 6373-71-3.mol
• Article Data: 25

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-cyclohexyl-2-nitroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: N-cyclohexyl-2-nitroaniline(6373-71-3)
• EPA Substance Registry System: N-cyclohexyl-2-nitroaniline(6373-71-3)

Safety Data

• Hazardous Substances Data: 6373-71-3(Hazardous Substances Data)

Usage

Uses

N-Cyclohexyl-2-nitroaniline is a useful reagent in the preparation of phenoxypyridine based oxo-dihydroquinoxaline derivatives used as c-Met kinase inhibitors.

Upstream product

• 609-73-4 o-nitroiodobenzene 
• 108-91-8 cyclohexylamine 
• 577-19-5 2-nitrophenyl bromide 
• 108-94-1 cyclohexanone 
• 88-74-4 2-nitro-aniline 
• 27122-72-1 Hexakis-<2-nitro-phenoxy>-cyclotriphosphonitril 
• 1493-27-2 ortho-nitrofluorobenzene 
• 88-73-3 2-Chloronitrobenzene 

Downstream Products

• 66536-70-7 1-cyclohexyl-1Hbenzo[d][1,2,3]triazole 
• 343326-73-8 (R)-(-)-1-tert-butylcarbonylmethyl-2-oxo-3-phenoxycarbonylamino-5-cyclohexyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine 
• 209219-38-5 (R)-(-)-3-[3-(1-tert-butylcarbonylmethyl-2-oxo-5-cyclohexyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-3-yl]ureido]benzoic acid 
• 209223-73-4 (R)-1-tert-butylcarbonylmethyl-2-oxo-3-tert-butoxycarbonylamino-5-cyclohexyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine 
• 252209-91-9 (R)-(-)-2-oxo-3-tert-butoxycarbonylamino-5-cyclohexyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine 
• 7397-96-8 N-phenyl-N'-cyclohexyl-o-phenylenediamine 
• 1428990-96-8 [RhCl(CO)₂(bis(1-cyclohexyl-3-methyl-benzimidazol-2-ylidene)methane)] 
• 1428990-92-4 bis(1-cyclohexyl-3-methyl-benzimidazol-2-ylidene)methane 

Relevant articles and documents

Biomimetic alloxan-catalyzed intramolecular redox reaction with O2: One-pot atom-economic synthesis of sulfinyl-functionalized benzimidazoles

Given the necessity of sacrificial reductants in various biomimetic aerobic oxygenations, alloxan-catalyzed aerobic redox system for one-pot atom-economic synthesis of sulfinyl-functionalized benzimidazoles was developed by ingeniously binding both the substrate sulfide and sacrificial reductant. This mild and transition-metal-free protocol undergoes two oxidations without additional sacrificial reagents, except for the environmentally benign molecular oxygen.

Design, synthesis, and biological evaluation of 4-phenoxyquinoline derivatives as potent c-Met kinase inhibitor

A series of novel 4-phenoxyquinoline derivatives containing 3-oxo-3,4-dihydro-quinoxaline moiety were synthesized and evaluated for their antiproliferative activity against five human cancer cell lines (A549, H460, HT-29, MKN-45 and U87MG) in vitro. Most of the tested compounds exhibited more potent inhibitory activities than the positive control foretinib. Compound 1b, 1s and 1t were further examined for their inhibitory activity against c-Met kinase. The most promising compound 1s (with c-Met IC50 value of 1.42 nM) showed remarkable cytotoxicity against A549, H460, HT-29, MKN45 and U87MG cell lines with IC50 values of 0.39 μM, 0.18 μM, 0.38 μM, 0.81 μM, respectively. Their preliminary structure-activity relationships (SARs) study indicated that the replacement of the aromatic ring with the cyclohexane improved their antiproliferative activity.

Diversity of the quaternary ammonium salt of the imidazole aryl and and its preparation method and application

The present invention discloses a diverse arylimidazole quaternary ammonium salt, a preparation method and an application thereof. The diverse arylimidazole quaternary ammonium salt is a compound represented by a formula (L-n'). The diverse arylimidazole quaternary ammonium salt has the following beneficial effects that: the diverse arylimidazole quaternary ammonium salt can be prepared through the one-pot method and is not prepared in a glove box, the raw material (aliphatic or aromatic imine) is subjected to the reaction, the yield is 78-94%, and the target product with high optical purity dr of more than 98:2 is obtained. According to the present invention, operations can be simplified, the yield can be increased, importantly an application range of the compound is expanded, and wide versatility is provided.