6361-23-5Relevant articles and documents
Efficient synthesis of acrylates bearing an aryl or heteroaryl moiety: One-pot method from aromatics and heteroaromatics using formylation and the horner-wadsworth-emmons reaction
Yasukata, Tatsuro,Matsuura, Takaharu
, p. 527 - 533 (2021/03/22)
Acrylates bearing an aryl or heteroaryl moiety were efficiently prepared by a one-pot process employing a sequence of lithiation, formylation and the Horner-Wadsworth-Emmons reaction starting from aromatic and heteroaromatic compounds. This method can efficiently introduce an acrylate moiety into aromatic and heteroaromatic compounds.
Monodentate Transient Directing Group Enabled Pd-Catalyzed Ortho-C-H Methoxylation and Chlorination of Benzaldehydes
Li, Feng,Zhou, Yirong,Yang, Heng,Wang, Ziqi,Yu, Qinqin,Zhang, Fang-Lin
supporting information, p. 3692 - 3695 (2019/05/24)
We report Pd-catalyzed ortho-C-H methoxylation and chlorination of benzaldehydes by employing monodentate transient directing groups (TDGs) as an alternative strategy to bidentate TDGs. More importantly, a single crystal of benzaldehyde imine ortho-cyclopalladium intermediate was successfully obtained, and its structure was unambiguously determined by X-ray diffraction, which clearly showed that it was a binuclear palladium species bridged by a pyridone ligand. The utility of this approach was further demonstrated through the synthesis of key intermediates of natural products and drugs.
Method for preparing 2,5-dichlorobenzaldehyde through continuous oxidation of 2,5-dichlorotoluene
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Paragraph 0030; 0032-0033; 0035-0036; 0038-0039; 0041-0042, (2017/07/19)
The invention provides a method for preparing 2,5-dichlorobenzaldehyde through continuous oxidation of 2,5-dichlorotoluene, belonging to the technical field of organic synthesis processes. According to the method, a 2,5-dichlorotoluene compound is used as a raw material; a metal ion complex of one or more selected from a group consisting of cobalt, molybdenum and bromine is used as a catalyst; hydrogen peroxide is used as an oxidizing agent; acetic acid is used as a solvent; and 2,5-dichlorotoluene is subjected to continuous oxidation in a tubular reactor so as to prepare 2,5-dichlorobenzaldehyde. The method provided by the invention is mild in conditions, short in reaction time, high in the utilization rate of raw materials, capable of realizing effective control of reaction process, safe, stable, continuous in operation and high in production efficiency.