63529-06-6

Basic information

• Product Name: 2-Propen-1-one, 1-(2-hydroxy-4-methoxyphenyl)-3-(4-hydroxyphenyl)-, (2E)-
• CAS NO: 63529-06-6
• Molecular Formula: C16H14O4
• Molecular Weight: 270.285
• Mol File: 63529-06-6.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2-Propen-1-one, 1-(2-hydroxy-4-methoxyphenyl)-3-(4-hydroxyphenyl)-, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-one, 1-(2-hydroxy-4-methoxyphenyl)-3-(4-hydroxyphenyl)-, (2E)-(63529-06-6)
• EPA Substance Registry System: 2-Propen-1-one, 1-(2-hydroxy-4-methoxyphenyl)-3-(4-hydroxyphenyl)-, (2E)-(63529-06-6)

Safety Data

• Hazardous Substances Data: 63529-06-6(Hazardous Substances Data)

Usage

General Description

2-Propen-1-one, 1-(2-hydroxy-4-methoxyphenyl)-3-(4-hydroxyphenyl)-(2E)- is a chemical compound with the molecular formula C15H14O4. It belongs to the class of chalcones, which are natural phenolic compounds found in various plants. This particular compound has a structural arrangement of a 1-(2-hydroxy-4-methoxyphenyl) group attached to a 3-(4-hydroxyphenyl) group through a 2-propen-1-one linker. It has been studied for its potential biological activities, including antioxidant, anti-inflammatory, and anticancer properties. Additionally, it has been identified as a potential candidate for drug development and as a natural product for various industrial applications.

Upstream product

• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 123-08-0 4-hydroxy-benzaldehyde 
• 6515-21-5 4-methoxymethoxy-benzaldehyde 
• 58544-83-5 1-[4-methoxy-2-(methoxymethoxy)phenyl]ethanone 
• 100-52-7 benzaldehyde 
• 23423-35-0 (E)‐3‐(4‐hydroxyphenyl)‐1‐(2,4‐dimethoxyphenyl)prop‐2‐en‐1‐one 
• 128837-26-3 4-(ethyloxymethoxy)benzaldehyde 
• 128961-25-1 1-(4-methoxy-2-((3-methylbut-2-en-1-yl)oxy)phenyl)ethan-1-one 
• 1314539-22-4 2'-geranyloxy-4'-methoxyacetophenone 
• 1314539-19-9 2'-hydroxyl-4'-methoxy-4-methoxymethoxychalcone 
• 1092462-95-7 4'-methoxy-4-methoxymethoxy-2'-prenyloxychalcone 
• 74189-56-3 4-(tetrahydropyran-2-yloxy)benzaldehyde 
• 651325-79-0 Acetic acid 4-[(E)-3-(2,4-dimethoxy-phenyl)-3-oxo-propenyl]-phenyl ester 
• 651325-80-3 3-bromo-1-(2,4-dimethoxy-phenyl)-propan-1-one 

Downstream Products

• 115123-09-6 (R)-2-(4-β-D-glucopyranosyloxy-phenyl)-7-methoxy-chroman-4-one 
• 32274-71-8 (R)-2-(4-hydroxy-phenyl)-7-methoxy-chroman-4-one 
• 84638-54-0 3-acetoxy-2-(4-acetoxy-phenyl)-7-methoxy-chromen-4-one 
• 120240-70-2 (2-hydroxy-4-methoxy-phenyl)-glyoxylic acid 
• 123-08-0 4-hydroxy-benzaldehyde 
• 84638-53-9 3-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one 
• 71005-52-2 (Z)-2-(4-hydroxybenzylidene)-6-methoxybenzofuran-3(2H)-one 
• 32274-71-8 7-Methylliquiritigenin 
• 62536-71-4 4'-methoxy-4.2'-diacetoxy-trans-chalcone 

Relevant articles and documents

COMPOSITIONS AND METHODS OF TREATING UPS-ASSOCIATED DISEASES

The present invention relates to methods for treating a disease characterized by aberrations in the ubiquitin/proteasome system (UPS).

Synthesis and antibacterial activity of chalcones bearing prenyl or geranyl groups from Angelica keiskei

Chalcones bearing prenyl or geranyl groups from Angelica keiskei, such as 4-hydroxyderricin (1a), xanthoangelol (1e), xanthoangelol F (1f), xanthoangelol H (2), deoxyxanthoangelol H (3), and deoxydihydroxanthoangelol H (4) and their derivatives were synthesized. From the evaluation of antibacterial activity of the synthesized chalcones, 1a, isobavachalcone (1b), 1e, 1f, bavachalcone (5a), and broussochalcone B (5b) were found to inhibit Gram-positive bacteria.

A new synthesis of flavonoids via Heck reaction

Several naturally occuring flavonoids have been synthesised following a new proposed method based on the use of the Heck reaction. The key step involves the coupling of an aryl vinyl ketone with an aryl iodide. This procedure affords the flavonoid moiety in a single step.