6351-10-6 Usage
Description
1-Indanol, also known as 1-hydroxyindane, is an organic compound with the molecular formula C9H10O. It is a colorless to pale yellow liquid with a characteristic odor. 1-Indanol is an important building block in the synthesis of various pharmaceuticals, agrochemicals, and other specialty chemicals due to its unique structure and reactivity.
Uses
1. Used in Pharmaceutical Industry:
1-Indanol is used as a pharmaceutical intermediate for the synthesis of various drugs. Its unique structure allows for the development of new and innovative medications with potential applications in treating a wide range of diseases and conditions.
2. Used in Chemical Synthesis:
1-Indanol is used as a key intermediate in the synthesis of various specialty chemicals, including agrochemicals and other industrial products. Its versatility as a building block makes it a valuable asset in the development of new and improved products.
3. Used in Catalysis:
1-Indanol derivatives have been found to be efficient ligands for the palladium-catalyzed asymmetric Heck reaction, a widely used method in organic synthesis. This application highlights the potential of 1-Indanol in the development of new and more efficient catalytic processes.
4. Used in Research and Development:
The chiral-sensitive aggregation of 1-indanol has been studied using techniques such as FTIR spectroscopy. This research contributes to a better understanding of the compound's properties and potential applications in various fields.
5. Used in Transfer Dehydrogenation:
1-Indanol has been investigated for its transfer dehydrogenation properties over heterogeneous palladium catalysts using cyclohexene as a hydrogen acceptor. This research could lead to the development of more efficient and environmentally friendly processes for the production of various chemicals and materials.
Check Digit Verification of cas no
The CAS Registry Mumber 6351-10-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,3,5 and 1 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 6351-10:
(6*6)+(5*3)+(4*5)+(3*1)+(2*1)+(1*0)=76
76 % 10 = 6
So 6351-10-6 is a valid CAS Registry Number.
InChI:InChI=1/C9H10O/c10-9-6-5-7-3-1-2-4-8(7)9/h1-4,9-10H,5-6H2
6351-10-6Relevant articles and documents
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Moss,Funk
, p. 2026 (1967)
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Jackson,McMullen
, p. 1170,1171 (1965)
Fe-Catalyzed Anaerobic Mukaiyama-Type Hydration of Alkenes using Nitroarenes
Bhunia, Anup,Bergander, Klaus,Daniliuc, Constantin Gabriel,Studer, Armido
supporting information, p. 8313 - 8320 (2021/03/08)
Hydration of alkenes using first row transition metals (Fe, Co, Mn) under oxygen atmosphere (Mukaiyama-type hydration) is highly practical for alkene functionalization in complex synthesis. Different hydration protocols have been developed, however, control of the stereoselectivity remains a challenge. Herein, highly diastereoselective Fe-catalyzed anaerobic Markovnikov-selective hydration of alkenes using nitroarenes as oxygenation reagents is reported. The nitro moiety is not well explored in radical chemistry and nitroarenes are known to suppress free radical processes. Our findings show the potential of cheap nitroarenes as oxygen donors in radical transformations. Secondary and tertiary alcohols were prepared with excellent Markovnikov-selectivity. The method features large functional group tolerance and is also applicable for late-stage chemical functionalization. The anaerobic protocol outperforms existing hydration methodology in terms of reaction efficiency and selectivity.
Selective Aerobic Oxidation of Secondary C (sp3)-H Bonds with NHPI/CAN Catalytic System
Wang, Lingyao,Zhang, Yuanbin,Yuan, Haoran,Du, Renfeng,Yao, Jia,Li, Haoran
, p. 1663 - 1669 (2020/10/21)
Abstract: The direct aerobic oxidation of secondarty C(sp3)-H bonds was achieved in the presence of N-hydroxyphthalimide (NHPI) and cerium ammonium nitrate (CAN) under mild conditions. Various benzylic methylenes could be oxidized to carbonyl compounds in satisfied selectivity while saturated cyclic alkanes could be further oxidized to the corresponding lactones with the catalytic system. Remarkably, 25% of isochroman was converted to corresponding ketone with a selectivity of 96%. The reaction was initiated by hydrogen atom abstraction from NHPI by cerium and nitrates under oxygen atmosphere to form PINO radicals. 2,2,6,6-Tetramethylpiperidine-1-oxyl (TEMPO) addition experiments showed that the oxidation proceeded via a complex radical chain mechanism and an ion pathway. Graphic Abstract: [Figure not available: see fulltext.]
