63471-85-2

Basic information

• Product Name: 4-(4-BENZYL-PHENYL)-4-OXO-BUTYRIC ACID
• Synonyms: 4-(4-BENZYL-PHENYL)-4-OXO-BUTYRIC ACID;TIMTEC-BB SBB012135
• CAS NO: 63471-85-2
• Molecular Formula: C₁₇H₁₆O₃
• Molecular Weight: 268.31
• Mol File: 63471-85-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 482.6°Cat760mmHg
• Flash Point: 259.7°C
• Appearance: /
• Density: 1.176g/cm³
• Vapor Pressure: 4.01E-10mmHg at 25°C
• Refractive Index: 1.585
• CAS DataBase Reference: 4-(4-BENZYL-PHENYL)-4-OXO-BUTYRIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-BENZYL-PHENYL)-4-OXO-BUTYRIC ACID(63471-85-2)
• EPA Substance Registry System: 4-(4-BENZYL-PHENYL)-4-OXO-BUTYRIC ACID(63471-85-2)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 63471-85-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C17H16O3/c18-16(10-11-17(19)20)15-8-6-14(7-9-15)12-13-4-2-1-3-5-13/h1-9H,10-12H2,(H,19,20)

Upstream product

• 108-30-5 succinic acid anhydride 
• 7446-70-0 aluminium trichloride 
• 101-81-5 Diphenylmethane 
• 98-95-3 nitrobenzene 

Downstream Products

• 1094213-90-7 (RS)-5-(4-benzylphenyl)dihydrofuran-2(3H)-one 
• 1094596-25-4 C₁₇H₁₈O₃ 
• 1356067-57-6 (+/-)-tetrahydro-2H-pyran-2-ylmethyl 4-(4-benzylphenyl)butanoate 
• 1356067-53-2 (+/-)-oxiran-2-ylmethyl 4-(4-benzylphenyl)butanoate 
• 221656-57-1 N,N-dimethyl-4-(diphenylmethylene)-n-butanamide 
• 221656-58-2 N,N-dimethyl-4-(diphenylmethylene)-n-butanamine 
• 18908-77-5 4-(4-Benzyl-phenyl)-4-oxo-butyric acid methyl ester 
• 63472-00-4 3-Brom-3-(4-Benzylbenzoyl)propionsaeure 
• 36330-88-8 3-(4-Benzoylbenzoyl)propionsaeure 
• 18908-85-5 4-{4-[4-(4-{4-[4-(3-Carboxy-propionyl)-benzyl]-benzoyl}-benzoyl)-benzyl]-phenyl}-4-oxo-butyric acid 
• 147862-73-5 4-(diphenylmethylene)-n-butanoic acid 

Relevant articles and documents

Synthesis, anti-convulsant activity and molecular docking study of novel thiazole pyridazinone hybrid analogues

Pyridazinone analogues have been known to be potential candidates for anticonvulsant agents. We have identified several pyridazinone-based anticonvulsant agents. As a continuation to our previous research, a series of hybrid pyridazinone-thiazole connected through amide linkage were designed and synthesized. Among these, compound SP-5F demonstrated significant anticonvulsant activity with median effective dose of 24.38 mg/kg (MES) and 88.23 mg/kg (scPTz). Results of GABA estimation showed a marked increase in the GABA level when compared with control. Molecular docking studies at the active site of GABA receptor, further confirmed the GABA modulatory effects of SP-5F.

Structure-activity relationship of a new series of reversible dual monoacylglycerol lipase/fatty acid amide hydrolase inhibitors

The two endocannabinoids, anandamide (AEA) and 2-arachidonoylglycerol (2-AG), play independent and nonredundant roles in the body. This makes the development of both selective and dual inhibitors of their inactivation an important priority. In this work we report a new series of inhibitors of monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH). Among them, (±)-oxiran-2-ylmethyl 6-(1,1′-biphenyl-4-yl)hexanoate (8) and (2R)-(-)-oxiran-2-ylmethyl(4-benzylphenyl)acetate (30) stand out as potent inhibitors of human recombinant MAGL (IC50 (8) = 4.1 μM; IC 50 (30) = 2.4 μM), rat brain monoacylglycerol hydrolysis (IC 50 (8) = 1.8 μM; IC50 (30) = 0.68 μM), and rat brain FAAH (IC50 (8) = 5.1 μM; IC50 (30) = 0.29 μM). Importantly, and in contrast to the other previously described MAGL inhibitors, these compounds behave as reversible inhibitors either of competitive (8) or noncompetitive nature (30). Hence, they could be useful to explore the therapeutic potential of reversible MAGL inhibitors.

Syntheses and antiinflammatory activity of some 6-aryl-2,3,4,5-tetrahydro-3-pyridazinones

6-Aryl-2, 3, 4, 5-tetrahydro-3-pyridazinones (2c-22c) are obtained by dehydrocyclisation of various hydrazides formed by the reaction of appropriate methyl β-aroylpropionate and hydrazine hydrate in the presence of anhydrous sodium acetate. They show promising antiinflammatory activity during their evaluation by carrageenin induced paw edema test in rats.