634602-13-4

Basic information

• Product Name: 2-(3-hydroxy-benzoyl)-benzoic acid
• Synonyms: 2-(3-hydroxy-benzoyl)-benzoic acid
• CAS NO: 634602-13-4
• Molecular Weight: 242.231
• Mol File: 634602-13-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(3-hydroxy-benzoyl)-benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-hydroxy-benzoyl)-benzoic acid(634602-13-4)
• EPA Substance Registry System: 2-(3-hydroxy-benzoyl)-benzoic acid(634602-13-4)

Safety Data

• Hazardous Substances Data: 634602-13-4(Hazardous Substances Data)

Upstream product

• 2159-38-8 2-(3'-nitrobenzoyl)benzoic acid 
• 85-52-9 2-Benzoylbenzoic acid 
• 6268-18-4 2-(3-amino-benzoyl)-benzoic acid 

Downstream Products

• 605-32-3 2-hydroxy-9,10-anthraquinone 
• 129-43-1 1-hydroxyanthraquinone 
• 857042-95-6 C₁₆H₁₄N₂O₂ 

Relevant articles and documents

The discovery of 1,2,3,9b-tetrahydro-5H-imidazo[2,1-a]isoindol-5-ones as a new class of respiratory syncytial virus (RSV) fusion inhibitors. Part 1

Respiratory syncytial virus (RSV) is a major cause of respiratory tract infections in infants, young children and adults. Compound 1a (9b-(4-chlorophenyl)-1-(4-fluorobenzoyl)-1,2,3,9b-tetrahydro-5H-imidazo[2,1-a]isoindol-5-one) was identified as an inhibitor of A and B strains of RSV targeting the fusion glycoprotein. SAR was developed by systematic exploration of the phenyl (R1) and benzoyl (R2) groups. Furthermore, introduction of a nitrogen at the 8-position of the tricyclic core resulted in active analogues with improved properties (aqueous solubility, protein binding and log D) and excellent rat pharmacokinetics (e.g., rat oral bioavailability of 89% for compound 17).