6312-87-4

Basic information

• Product Name: N-(4-PHENOXY-PHENYL)-ACETAMIDE
• Synonyms: N-(4-PHENOXY-PHENYL)-ACETAMIDE;Ccris 7394;N-(4-Phenoxyphenyl)
• CAS NO: 6312-87-4
• Molecular Formula: C₁₄H₁₃NO₂
• Molecular Weight: 227.25852
• Mol File: 6312-87-4.mol
• Article Data: 30

Chemical Properties

• Melting Point: 106-107 °C
• Boiling Point: 410.8 °C at 760 mmHg
• Flash Point: 202.2 °C
• Appearance: /
• Density: 1.176 g/cm³
• Vapor Pressure: 5.87E-07mmHg at 25°C
• Refractive Index: 1.61
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.36±0.70(Predicted)
• CAS DataBase Reference: N-(4-PHENOXY-PHENYL)-ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-PHENOXY-PHENYL)-ACETAMIDE(6312-87-4)
• EPA Substance Registry System: N-(4-PHENOXY-PHENYL)-ACETAMIDE(6312-87-4)

Safety Data

• Hazardous Substances Data: 6312-87-4(Hazardous Substances Data)

Usage

General Description

N-(4-phenoxy-phenyl)-acetamide is a chemical compound with the molecular formula C14H13NO2. It is an amide derivative with a phenyl group substituted at the 4-position of the phenoxy group. N-(4-PHENOXY-PHENYL)-ACETAMIDE is commonly used in organic synthesis and pharmaceutical research as a building block for the synthesis of other organic molecules. It may also have potential biological activities and is being investigated for its potential use in medicinal chemistry. Additionally, it is important to handle this compound with care as it may have certain hazards associated with its handling and use.

InChI:InChI=1/C14H13NO2/c1-11(16)15-12-7-9-14(10-8-12)17-13-5-3-2-4-6-13/h2-10H,1H3,(H,15,16)

Upstream product

• 64-19-7 acetic acid 
• 139-59-3 4-phenoxyanilin 
• 108-86-1 bromobenzene 
• 103-90-2 4-acetaminophenol 
• 6337-25-3 1-(4-phenoxyphenyl)ethan-1-one oxime 
• 14040-11-0 tungsten hexacarbonyl 
• 620-88-2 4-nitrophenyl phenyl ether 
• 616-38-6 carbonic acid dimethyl ester 
• 6337-25-3 1-(4-phenoxy-phenyl)-ethanone oxime 
• 75-05-8 acetonitrile 
• 591-50-4 iodobenzene 
• 66003-76-7 Diphenyliodonium triflate 
• 103-88-8 4-bromoacetanilide 
• 108-95-2 phenol 

Downstream Products

• 60854-00-4 2-nitro-4-phenoxyphenylamine 
• 28896-49-3 bis(4-iodophenyl) ether 
• 620-55-3 1-nitro-3-phenoxybenzene 
• 58518-73-3 4-(4-iodo-phenoxy)-aniline 
• 171349-99-8 N-ethyl-4-phenoxyaniline 
• 1120334-11-3 2-bromo-6-nitro-4-phenoxyphenylamine 
• 139-59-3 4-phenoxyanilin 
• 1613336-62-1 3,5-diiodo-2-methoxy-N-methyl-N-(4-phenoxyphenyl)benzamide 
• 1613336-61-0 2-hydroxy-3,5-diiodo-N-methyl-N-(4-phenoxyphenyl)benzamide 
• 72920-03-7 para-phenoxy-N-methylaniline 
• 92163-23-0 2-methyl-6-phenoxy-benzothiazole 
• 315248-48-7 N-acetyl-sulfanilic acid-(4-phenoxy-anilide) 
• 855761-40-9 8-nitro-6-phenoxy-quinoline 
• 855837-35-3 6-phenoxy-[8]quinolylamine 

Relevant articles and documents

A novel construction of acetamides from rhodium-catalyzed aminocarbonylation of DMC with nitro compounds

Dimethyl carbonate (DMC), an environment-friendly compound prepared from CO2, shows diverse reactivities. In this communication, an efficient procedure using DMC as both a C1 building block and solvent in the aminocarbonylation reaction with nitro compounds has been developed. W(CO)6acts both a CO source and a reductant here.

Visible-light-induced Beckmann rearrangement by organic photoredox catalysis

A facile and general strategy for efficient direct conversion of oximes to amides using an inexpensive organic photocatalyst and visible light is described. This radical Beckmann rearrangement can be performed under mild conditions. Various alkyl aryl ketoximes and diaryl ketoximes can be effectively converted into the corresponding amides in excellent yields.

An Electrochemical Beckmann Rearrangement: Traditional Reaction via Modern Radical Mechanism

Abstract: Electrosynthesis as a potential means of introducing heteroatoms into the carbon framework is rarely studied. Herein, the electrochemical Beckmann rearrangement, i. e. the direct electrolysis of ketoximes to amides, is presented for the first time. Using a constant current as the driving force, the reaction can be easily carried out under neutral conditions at room temperature. Based on a series of mechanistic studies, a novel radical Beckmann rearrangement mechanism is proposed. This electrochemical Beckmann rearrangement does not follow the trans-migration rule of the classical Beckmann rearrangement.