6310-17-4

Basic information

• Product Name: 2-bromo-4-nitro-1-tert-butyl-benzene
• Synonyms: 2-bromo-4-nitro-1-tert-butyl-benzene;2-BROMO-1-TERT-BUTYL-4-NITROBENZEN;2-bromo-1-(tert-butyl)-4-nitrobenzene(WX191811)
• CAS NO: 6310-17-4
• Molecular Formula: C₁₀H₁₂BrNO₂
• Molecular Weight: 258.11
• Mol File: 6310-17-4.mol
• Article Data: 16

Chemical Properties

• Melting Point: 93-94 °C
• Boiling Point: 298°C at 760 mmHg
• Flash Point: 134°C
• Appearance: /
• Density: 1.401g/cm³
• Vapor Pressure: 0.00232mmHg at 25°C
• Refractive Index: 1.552
• CAS DataBase Reference: 2-bromo-4-nitro-1-tert-butyl-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-4-nitro-1-tert-butyl-benzene(6310-17-4)
• EPA Substance Registry System: 2-bromo-4-nitro-1-tert-butyl-benzene(6310-17-4)

Safety Data

• Hazardous Substances Data: 6310-17-4(Hazardous Substances Data)

Usage

Description

2-bromo-4-nitro-1-tert-butyl-benzene is an organic compound that features a benzene ring with a bromine atom, a nitro group, and a tert-butyl group as substituents. 2-bromo-4-nitro-1-tert-butyl-benzene is known for its versatility in organic synthesis and its potential applications across various industries.

Uses

Used in Pharmaceutical Industry:
2-bromo-4-nitro-1-tert-butyl-benzene is used as a synthetic intermediate for the development of various pharmaceuticals. Its unique structure, including the bromine and nitro groups, allows for the creation of complex molecules that can be utilized in medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 2-bromo-4-nitro-1-tert-butyl-benzene serves as a key intermediate in the synthesis of compounds used in agriculture. Its properties make it suitable for the development of new agrochemicals that can enhance crop protection and productivity.
Used in Organic Synthesis:
2-bromo-4-nitro-1-tert-butyl-benzene is used as a reagent in organic synthesis due to the reactivity of its bromine and nitro groups. These functional groups can participate in a variety of chemical reactions, enabling the formation of diverse organic compounds for various applications.
Used in Research and Development:
2-bromo-4-nitro-1-tert-butyl-benzene is also utilized in research and development settings to explore new chemical reactions and pathways. Its structural characteristics make it an interesting subject for studies aimed at understanding and optimizing synthetic processes in chemistry.

InChI:InChI=1/C10H12BrNO2/c1-10(2,3)8-5-4-7(12(13)14)6-9(8)11/h4-6H,1-3H3

Upstream product

• 253185-03-4 tert-butylbenzene 
• 3282-56-2 4-tert-butylnitrobenzene 

Downstream Products

• 873056-38-3 (2-tert-butyl-5-aminophenyl)methanol 
• 873056-34-9 methyl 2-tert-butyl-5-aminobenzoate 
• 873056-28-1 2-(tert-butyl)-5-nitrobenzonitrile 
• 1610416-92-6 2-(tert-butyl)-5-(methoxymethyl)benzonitrile 
• 1369886-14-5 5-bromo-2-(tert-butyl)benzonitrile 
• 873056-33-8 methyl 2-tert-butyl-5-nitrobenzoate 
• 14034-90-3 2-tert-butyl-5-nitrobenzoic acid 
• 873056-32-7 tert-butyl 2-tert-butyl-5-aminobenzylcarbamate 
• 873056-31-6 tert-butyl 2-tert-butyl-5-nitrobenzylcarbamate 
• 873056-30-5 (2-tert-butyl-5-nitrophenyl)methanamine 
• 873056-29-2 5-amino-2-(tert-butyl)benzonitrile 
• 103275-21-4 3-bromo-4-(tert-butyl)aniline 
• 1135494-90-4 1-[4-bromo-5-(tert-butyl)-2-nitrophenyl]-4-methylpiperazine 
• 63818-32-6 Benzyl-o-tert.-butylphenylsulfon 

Relevant articles and documents

Nucleophilic Iron Complexes in Proton-Transfer Catalysis: An Iron-Catalyzed Dimroth Cyclocondensation

The nucleophilic iron complex Bu4N[Fe(CO)3(NO)] (TBA[Fe]) is an active catalyst in C?H-amination but also in proton-transfer catalysis. Herein, we describe the successful use of this complex as a proton-transfer catalyst in the cyclocondensation reaction between azides and ketones to the corresponding 1,2,3-triazoles. Cross-experiments indicate that the proton-transfer catalysis is significantly faster than the nitrene-transfer catalysis, which would lead to the C?H amination product. An example of a successful sequential Dimroth triazole–indoline synthesis to the corresponding triazole-substituted indolines is presented.

Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases

The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.

N-(ARYLALKYL)-N'-PYRAZOLYL-UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS

Compounds of Formula I or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C, X, Ra, Rb, Rc, Rd and n are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome.