62803-47-8

Basic information

• Product Name: 6-Hydroxy-1-indanone
• Synonyms: 6-HYDROXY-1-INDANONE;6-HYDROXY-1-INDANONE 99%;6-Hydrocy-2,3-Dihydro-1H-Inden-1-One;6-Hydroxy-1-Indenone;2,3-Dihydro-6-hydroxy-1H-inden-1-one;6-Hydroxyindan-1-one;6-Hydroxy-2,3-dihydro-1H-inden-1-one;6-hydroxy-2,3-dihydroinden-1-one
• CAS NO: 62803-47-8
• Molecular Formula: C₉H₈O₂
• Molecular Weight: 148.16
• Product Categories: Indanone & Indene;C9;Carbonyl Compounds;Ketones;Building Blocks;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
• Mol File: 62803-47-8.mol
• Article Data: 23

Chemical Properties

• Melting Point: 154-158 °C(lit.)
• Boiling Point: 329 °C at 760 mmHg
• Flash Point: 139.8 °C
• Appearance: white to light yellow crystal powder
• Density: 1.305 g/cm³
• Vapor Pressure: 9.51E-05mmHg at 25°C
• Refractive Index: 1.631
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 9.45±0.20(Predicted)
• CAS DataBase Reference: 6-Hydroxy-1-indanone(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Hydroxy-1-indanone(62803-47-8)
• EPA Substance Registry System: 6-Hydroxy-1-indanone(62803-47-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/38-43
• Safety Statements: 26-36/37
• WGK Germany: 2
• Hazardous Substances Data: 62803-47-8(Hazardous Substances Data)

Usage

Description

6-Hydroxy-1-indanone is a white to light yellow crystal powder that serves as a crucial intermediate in the synthesis of various organic compounds, particularly in the pharmaceutical industry.

Uses

Used in Pharmaceutical Industry:
6-Hydroxy-1-indanone is used as a key intermediate for the synthesis of tetracyclic ketones in the total syntheses of (±)-frondosin C and (±)-8-epi-frondosin C. These compounds have potential applications in the development of new drugs.
Additionally, 6-Hydroxy-1-indanone is used as a precursor in the synthesis of 1,4-dihydroindeno[1,2-c]pyrazoles, which act as potent CHK-1 inhibitors. These inhibitors play a significant role in the development of cancer treatments by inhibiting the growth of cancer cells.

InChI:InChI=1/C9H8O2/c10-7-3-1-6-2-4-9(11)8(6)5-7/h1,3,5,10H,2,4H2

Upstream product

• 13623-25-1 6-methoxy-2,3-dihydro-1H-inden-1-one 
• 83-33-0 inden-1-one 
• 1929-29-9 3-(4-methoxyphenyl)propanoic acid 
• 23795-02-0 3-(4-hydroxy-phenyl)-propionic acid ethyl ester 
• 2979-06-8 ethyl (E)-4-hydroxycinnamate 
• 5597-50-2 3-(4-hydroxyphenyl)propionic acid methyl ester 
• 881181-71-1 3-(1-methoxy-4-oxocyclohexa-2,5-dien-1-yl)propanal 
• 830-09-1 3-(4'-methoxyphenyl)propenoic acid 
• 15893-42-2 3-(4-methoxyphenyl)propionyl chloride 
• 123-11-5 4-methoxy-benzaldehyde 
• 943-89-5 (E)-3-(4-methoxyphenyl)acrylic acid 
• 2973-80-0 2-bromo-5-hydroxybenzaldehyde 
• 1313762-42-3 5-hydroxy-2-vinylbenzaldehyde 
• 645-45-4 hydrocinnamic acid chloride 

Downstream Products

• 62803-59-2 6-Phenoxy-1-indanon 
• 320574-77-4 6-hydroxy-7-allyl-indan-1-one 
• 90563-78-3 7-ammino-2,3-diidro-6-idrossi-1H-indene-1-one 
• 61346-52-9 6-Phenyl-1-indancarbonsaeure 
• 186910-47-4 6-[O-Trifluoroacetyl]-hydroxyindan-1-one 
• 108-95-2 phenol 
• 25083-80-1 6-(benzyloxy)-2,3-dihydro-1H-inden-1-one 

Relevant articles and documents

A metal-free method for the facile synthesis of indanonesviathe intramolecular hydroacylation of 2-vinylbenzaldehyde

A facile method for the synthesis of indanones was developed under metal- and additive-free conditions, whereinl-proline served as an efficient and environmentally benign catalyst. Compared with previously synthesized indanones, synthesis by the transition-metal-catalyzed intramolecular hydroacylation of 2-vinylbenzaldehyde provided a more green synthetic pathway to indanone scaffolds with good to excellent yields. More importantly, it could be used to synthsize the anti-AD drug donepezil.

Effect of ring size on photoisomerization properties of stiff stilbene macrocycles

A series of stiff stilbene macrocycles have been studied to investigate the possible impact of the macrocycle ring size on their photodynamic properties. The results show that reducing the ring size counteracts the photoisomerization ability of the macrocycles. However, even the smallest macrocycle studied (stiff stilbene subunits linked by a six carbon chain) showed some degree of isomerization when irradiated. DFT calculations of the energy differences between the E- and Z-isomers show the same trend as the experimental results. Interestingly the DFT study highlights that the energy difference between the E- and Z-isomers of even the largest macrocycle (linked by a twelve carbon chain) is significantly higher than that of the stiff stilbene unit itself. In general, it is indicated that addition of even a flexible chain to the stiff stilbene unit may significantly affect its photochemical properties and increase the photostability of the resulting macrocycle.

Enantioselective bioreduction of benzo-fused cyclic ketones with engineered: Candida glabrata ketoreductase 1-a promising synthetic route to ladostigil (TV3326)

Biocatalysis has been recently emerging as a promising alternative to traditional chemical synthesis because of its "green" characteristics and comparable selectivities, which accord with the concept of sustainable development and demand for asymmetric synthesis. In this study, whole-cell biocatalysts containing glucose dehydrogenase (GDH) and Candida glabrata ketoreductase 1 (CgKR1) variants were constructed. These biocatalysts were applied to the reduction of benzo-fused cyclic ketones and showed good to high activities and enantioselectivities. Particularly, CgKR1 variants displayed high activities (90.6%-98.4% conversions) and enantioselectivities (>99.9% ee) towards 5a, a key intermediate of ladostigil (TV3326). Based on these results, a chemoenzymatic synthesis of (S)-5b was developed by using biocatalytic asymmetric reduction as a key step, giving the product with a total yield of 34.0% and 99.9% ee.