6269-27-8

Basic information

• Product Name: 3-Chloro-9(10H)-acridinone
• Synonyms: 3-Chloro-9(10H)-acridinone
• CAS NO: 6269-27-8
• Molecular Formula: C₁₃H₈ClNO
• Molecular Weight: 229.66
• Mol File: 6269-27-8.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 390.6°C at 760 mmHg
• Flash Point: 190°C
• Appearance: /
• Density: 1.346g/cm³
• Vapor Pressure: 2.63E-06mmHg at 25°C
• Refractive Index: 1.649
• CAS DataBase Reference: 3-Chloro-9(10H)-acridinone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-9(10H)-acridinone(6269-27-8)
• EPA Substance Registry System: 3-Chloro-9(10H)-acridinone(6269-27-8)

Safety Data

• Hazardous Substances Data: 6269-27-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H8ClNO/c14-8-5-6-10-12(7-8)15-11-4-2-1-3-9(11)13(10)16/h1-7H,(H,15,16)

Upstream product

• 59304-30-2 6-chloroacridine 
• 38046-68-3 3-(4-chlorophenyl)benzo[c]isoxazole 
• 50433-64-2 3-amino-10H-acridin-9-one 
• 35547-70-7 3,9-dichloroacridine 
• 108-90-7 chlorobenzene 
• 552-89-6 2-nitro-benzaldehyde 
• 13278-36-9 N-(3-chlorophenyl)anthranilic acid 
• 5551-11-1 4-Chloro-2-nitrobenzaldehyde 
• 71-43-2 benzene 
• 19218-88-3 N-phenyl-4-chloroanthranilic acid 
• 50-84-0 2,4 dichlorobenzoic acid 
• 62-53-3 aniline 
• 108-42-9 3-chloro-aniline 
• 118-91-2 ortho-chlorobenzoic acid 

Downstream Products

• 59304-30-2 6-chloroacridine 
• 35547-70-7 3,9-dichloroacridine 
• 70974-00-4 10-benzyl-3-chloroacridin-9(10H)-one 
• 3407-98-5 5-Amino-2-chloroacridin 
• 270088-53-4 3-Chloro-9-(4-nitro-phenylsulfanyl)-acridine 

Relevant articles and documents

Access to acridones by tandem copper(i)-catalyzed electrophilic amination/Ag(i)-mediated oxidative annulation of anthranils with arylboronic acids

An efficient and practical approach for the synthesis of medicinally important acridones was developed from anthranils and commercially available arylboronic acids by a tandem copper(i)-catalyzed electrophilic amination/Ag(i)-mediated oxidative annulation strategy. This new and straightforward protocol displayed a broad substrate scope (25 examples) and high functional group tolerance. What's more, a possible mechanistic proposal was also presented.

Pd-NHC catalysed Carbonylative Suzuki coupling reaction and its application towards the synthesis of biologically active 3-aroylquinolin-4 (1H)-one and acridone scaffolds

We have unfolded a convenient and mild protocol for the synthesis of diaryl ketones via Pd- NHC catalysed carbonylative Suzuki coupling reaction. Notably, this method offers advantages like no use of toxic CO gas, shorter reaction time, high yield, and broad substrate scope. Several sensitive functional groups (like-COMe, -COOMe, -F, -Cl, -Br, -NH2, -CN) are well tolerated in this reaction. In addition, we have also demonstrated a new efficient route for the synthesis of biologically active and pharmaceutically important 2-substituted 3-Aroylquinolin-4(1H)-ones and acridone scaffolds.

Tandem arylation/friedel-crafts reactions of o-acylanilines with diaryliodonium salts: A modular synthesis of acridine derivatives

A modular method to synthesize acridine derivatives was developed with o-acylanilines and diaryliodonium salts. The reactions proceeded smoothly under Cu-catalyzed or metal-free reaction conditions at elevated temperature through tandem arylation/Friedel-Crafts reactions.