62666-20-0 Usage
Description
Progabide, also known by its brand names Gabren, Gabaphore, SL 76 002, and GABRENE, is a broad-spectrum anticonvulsant agent. It is a gamma-aminobutyric acid (GABA) antagonist with antiepileptic activity, synthesized as a GABA-prodrug. Its anticonvulsant properties are attributed to the parent drug, its acid metabolite, and the GABAmide and GABA liberated from it. Progabide is characterized by its bright yellow solid appearance and is primarily indicated for the treatment of a wide variety of seizure disorders.
Uses
Used in Pharmaceutical Industry:
Progabide is used as an anticonvulsant for the treatment of various seizure disorders. Its gamma-aminobutyric acid (GABA) antagonist properties help in managing and reducing the frequency and severity of seizures, providing relief to patients suffering from epilepsy and other related conditions.
Used in Neurological Applications:
In the field of neurology, Progabide is utilized for its antiepileptic activity. It aids in the management of seizure disorders by targeting the GABAergic system, which plays a crucial role in regulating neuronal excitability and inhibiting seizures. This application contributes to the overall well-being and quality of life for patients with neurological conditions.
Originator
Synthelabo (France)
World Health Organization (WHO)
Progabide, an anticonvulsant, was introduced in France in 1985
for the treatment of epilepsy. Its use has occasionally been associated with
clinically evident signs of icteric hepatitis developing within the first six months of
treatment. These signs are generally reversible on withdrawal of the drug but
continuation of treatment has been associated with three reported fatalities (two of
which are doubtfully related to the drug). The manufacturer revised the data sheet
in March 1986 advising that use of progabide should be reserved for patients
unresponsive to other anticonvulsants.
Check Digit Verification of cas no
The CAS Registry Mumber 62666-20-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,2,6,6 and 6 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 62666-20:
(7*6)+(6*2)+(5*6)+(4*6)+(3*6)+(2*2)+(1*0)=130
130 % 10 = 0
So 62666-20-0 is a valid CAS Registry Number.
InChI:InChI=1/C17H16ClFN2O2/c18-12-5-3-11(4-6-12)17(21-9-1-2-16(20)23)14-10-13(19)7-8-15(14)22/h3-8,10,22H,1-2,9H2,(H2,20,23)/b21-17+