626-67-5Relevant articles and documents
Synthesis and characterization of substituted (aminomethyl)lithium compounds: The structures of [Li2(CH2NPh2)2(THF)3] and [Li4(CH2NC5H10)4(THF)2]
Becke, Frank,Heinemann, Frank W.,Rueffer, Tobias,Wiegeleben, Peter,Boese, Roland,Blaeser, Dieter,Steinborn, Dirk
, p. 205 - 210 (1997)
(Aminomethyl)lithium compounds LiCH2NRR′ · x THF (NRR′ = NMe2 (1a, x = 0), NPhMe (1b, x = 2), NPh2 (1c, x = 1 ... 1,5), NC5H10 (1d, x = 0, NC5H10 = piperidino), and NC7H14 (1e, NC7H14 = 2,6-dimethylpiperidino)) were prepared by the reaction of Bu3SnCH2NRR′ with BuLi. 1a-d were isolated in solid state and characterized by NMR spectroscopy (1H, 13C, 7Li). 1e was obtained in solution and characterized via reaction with MeOH and with benzophenone to generate MeNC7H14 and Ph2C(OH)CH2NC7H14, respectively. Recrystallization of 1c and 1d from n-hexane/THF gives [Li2(CH2NPh2)2(THF)3] (1c′) and [Li4(CH2NC5H10)4(THF)2] (1d′), respectively, whose structures (X-ray) were determined. The dimeric compound 1c′ forms a central planar four-membered Li2C2 ring. One lithium atom is four-coordinated to two methylene carbon atoms (d(Li-C) = 2.246(9), 2.235(9) A) and two oxygen atoms of THF. Unusually, the second lithium exhibits a nearly planar coordination sphere represented by two methylene carbon atoms (d(Li-C) = 2.17(1) and 2.16(1) A) and by the oxygen atom of the disordered THF molecule. 1d′ is a tetrameric species exhibiting a molecular C2 symmetry. The lithium atoms are arranged in a distorted tetrahedron with methylene carbon atoms occupying each face of the tetrahedron.
Reduction of Amides to Amines with Pinacolborane Catalyzed by Heterogeneous Lanthanum Catalyst La(CH2C6H4NMe2- o)3@SBA-15
Guo, Chenjun,Zhang, Fangcao,Yu, Chong,Luo, Yunjie
supporting information, p. 13122 - 13135 (2021/08/31)
Hydroboration of amides is a useful synthetic strategy to access the corresponding amines. In this contribution, it was found that the supported lanthanum benzyl material La(CH2C6H4NMe2-o)3@SBA-15 was highly active for the hydroboration of primary, secondary, and tertiary amides to amines with pinacolborane. These reactions selectively produced target amines and showed good tolerance for functional groups such as -NO2, -halogen, and -CN, as well as heteroatoms such as S and O. This reduction procedure exhibited the recyclable and reusable property of heterogeneous catalysts and was applicable to gram-scale synthesis. The reaction mechanisms were proposed based on some control experiments and the previous literature. This is the first example of hydroborative reduction of amides to amines mediated by heterogeneous catalysts.
Germyliumylidene: A Versatile Low Valent Group 14 Catalyst
Sarkar, Debotra,Dutta, Sayan,Weetman, Catherine,Schubert, Emeric,Koley, Debasis,Inoue, Shigeyoshi
supporting information, p. 13072 - 13078 (2021/08/09)
Bis-NHC stabilized germyliumylidenes [RGe(NHC)2]+ are typically Lewis basic (LB) in nature, owing to their lone pair and coordination of two NHCs to the vacant p-orbitals of the germanium center. However, they can also show Lewis acidity (LA) via Ge?CNHC σ* orbital. Utilizing this unique electronic feature, we report the first example of bis-NHC-stabilized germyliumylidene [MesTerGe(NHC)2]Cl (1), (MesTer=2,6-(2,4,6-Me3C6H2)2C6H3; NHC= IMe4=1,3,4,5-tetramethylimidazol-2-ylidene) catalyzed reduction of CO2 with amines and arylsilane, which proceeds via its Lewis basic nature. In contrast, the Lewis acid nature of 1 is utilized in the catalyzed hydroboration and cyanosilylation of carbonyls, thus highlighting the versatile ambiphilic nature of bis-NHC stabilized germyliumylidenes.
Method for synthesizing methyl piperidine through 1- supported metal catalysis (by machine translation)
-
Paragraph 0014-0021, (2020/01/25)
The invention provides a supported metal-catalyzed synthesis method of methyl 1 - piperidine through a supported, metal, wherein the supported metal is, 1,5 - used as catalyst stanediol and methylamine as H a raw material (I) in the following, formula (I). 2 The supported metal, catalyst comprises 230-330 °C, a carrier and 2-4Mpa an active 1-8h, component 1 - wherein. the supported metal catalyst comprises a carrier and an active component: wherein the supported Cu, Ni, Pd/Ru, metal catalyst comprises Cu a Ni carrier and an active component, wherein 3-15%, the Cu total Ni supported amount of 1:1;Pd/Ru the active component (s) 0-1%; and the mass Al ratio (mass ratio) of the active component (s) to the mass of the carrier (s) is in the range. 2 O3 , SiO2 Alternatively, the ZSM - 5. present invention catalyzes the preparation of 1 - a production, 1,5 - route with an 100%,1 - actual application value by a 93%, one-pot process for the catalytic preparation of the conversion rate of methyl.piperidine-pentanediol to methyl piperidine. (by machine translation)
