626-05-1 Usage
Description
2,6-Dibromopyridine is an organic compound with the chemical formula C5H3Br2N. It is a derivative of pyridine, a heterocyclic aromatic compound, where two bromine atoms are attached to the 2nd and 6th positions of the pyridine ring. 2,6-Dibromopyridine is known for its potential applications in various chemical and pharmaceutical processes due to its unique structure and properties.
Uses
Used in Chemical Synthesis:
2,6-Dibromopyridine is used as a tridentate chelating ligand for the formation of metal complexes. Its ability to bind with metal ions through multiple donor atoms makes it a versatile building block in the synthesis of coordination compounds with potential applications in catalysis, sensing, and materials science.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,6-Dibromopyridine is utilized in the synthesis of macrocycles containing the terpyridine moiety. These macrocyclic compounds have attracted significant interest due to their potential use as drug candidates, particularly in the development of new antibiotics, antitumor agents, and other therapeutic agents.
Used in Organic Synthesis:
2,6-Dibromopyridine is also used as a key intermediate in the production of various organic compounds. For example, it can be converted to 6-bromo-2-methoxypyridine, which can further be used in the synthesis of other pyridine-based compounds with potential applications in various fields, such as agrochemicals, dyes, and pharmaceuticals.
Purification Methods
Purify 2,6-dibromopyridine by steam distillation, then recrystallise it twice from EtOH. It does not form an HgCl2 salt. [den Hertog & Wibaut Recl Trav Chim Pays Bas 51 381 1932, Beilstein 20/5 V 435.]
Check Digit Verification of cas no
The CAS Registry Mumber 626-05-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,2 and 6 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 626-05:
(5*6)+(4*2)+(3*6)+(2*0)+(1*5)=61
61 % 10 = 1
So 626-05-1 is a valid CAS Registry Number.
InChI:InChI=1/C5H3Br2N/c6-4-2-1-3-5(7)8-4/h1-3H
626-05-1Relevant articles and documents
A simple base-mediated halogenation of acidic sp2 C-H bonds under noncryogenic conditions
Do, Hien-Quang,Daugulis, Olafs
supporting information; experimental part, p. 421 - 423 (2009/07/04)
(Chemical Equation Presented) A new method has been developed for in situ halogenation of acidic sp2 carbon-hydrogen bonds in heterocycles and electron-deficient arenes. Either selective monohalogenation or one-step exhaustive polyhalogenation is possible for substrates possessing several C-H bonds that are flanked by electron-withdrawing groups. For the most acidic arenes, such as pentafluorobenzene, K3PO4 base can be employed instead of BuLi for metalation/halogenation sequences.
Process for the synthesis of an endothelin receptor antagonist
-
, (2008/06/13)
The present invention relates to a practical and efficient way to synthesize the compound for the endothelin receptor antagonist involving a Grignard addition and a cyclization reaction to give a desired compound of the general formula shown below:
Titanium(0) Reagents; 2. A Selective and Efficient Deoxygenation of Halogen Containing Heteroaromatic N-Oxides
Malinowski, Marek,Kaczmarek, Lukasz
, p. 1013 - 1015 (2007/10/02)
Following successful reductions of unfunctionalized heteroaromatic N-oxides by titanium(0), we applied this method to halogenated aromatic N-oxides to give the deoxygenated halogeno derivatives in 90-95percent yield.