62287-47-2Relevant articles and documents
Synthesis of podophyllotoxin analogues: δ-lactone-containing picropodophyllin, podophyllotoxin and 4′-demethyl-epipodophyllotoxin derivatives
Meresse, Philippe,Monneret, Claude,Bertounesque, Emmanuel
, p. 2657 - 2671 (2007/10/03)
Non-epimerizable cis and trans δ-lactone analogues of podophyllotoxin have been prepared. Thus the synthesis of the cis isomer 4 has been achieved in 8 steps and 4% overall yield from podophyllotoxin 1 via the reduction of the γ lactone ring into the tran
Cytotoxic cyclolignans related to podophyllotoxin
Gordaliza, Marina,Miguel Del Corral, Jose M.,Angeles Castro,Garcia-Garcia, Pablo A.,San Feliciano, Arturo
, p. 297 - 304 (2007/10/03)
The cyclolignan family of natural products includes compounds with important antineoplastic and antiviral properties such as podophyllotoxin and two of their semisynthetic derivatives, etoposide and teniposide. The latter are included in a wide variety of