622-61-7

Basic information

• Product Name: 4-CHLOROPHENETOLE
• Synonyms: P-CHLOROETHOXYBENZENE;P-CHLOROPHENETOLE;1-chloro-4-ethoxy-benzen;1-Ethoxy-chlorobenzene;4-Chlorophenol ethyl ether;Benzene, 1-chloro-4-ethoxy-;benzene,1-chloro-4-ethoxy-;chlorophenentole
• CAS NO: 622-61-7
• Molecular Formula: C₈H₉ClO
• Molecular Weight: 156.61
• EINECS: 210-747-6
• Product Categories: Phenetole
• Mol File: 622-61-7.mol
• Article Data: 23

Chemical Properties

• Melting Point: 17°C
• Boiling Point: 214 °C
• Flash Point: 17 °C
• Appearance: /
• Density: 1,13 g/cm3
• Refractive Index: 1.5240-1.5280
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-CHLOROPHENETOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLOROPHENETOLE(622-61-7)
• EPA Substance Registry System: 4-CHLOROPHENETOLE(622-61-7)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 622-61-7(Hazardous Substances Data)

Usage

General Description

4-Chlorophenetole, also known as para-chlorophenetole, is a chemical compound with the molecular formula C8H9ClO. It is a colorless liquid with a sweet, floral odor, and it is often used as a fragrance and flavoring agent in various consumer products. 4-Chlorophenetole is also used in the production of perfumes, as well as in the synthesis of other chemicals such as pharmaceuticals and agrochemicals. However, it is important to handle 4-Chlorophenetole with care, as it can be harmful if ingested or inhaled, and it may cause skin and eye irritation upon contact.

InChI:InChI=1/C8H9ClO/c1-2-10-8-5-3-7(9)4-6-8/h3-6H,2H2,1H3

Upstream product

• 156-43-4 4-Ethoxyaniline 
• 67-64-1 acetone 
• 103-73-1 Phenetole 
• 7647-01-0 hydrogenchloride 
• 64-17-5 ethanol 
• 352-33-0 1-Chloro-4-fluorobenzene 
• 108-01-0 2-(N,N-dimethylamino)ethanol 
• 106-48-9 4-chloro-phenol 
• 105-58-8 Diethyl carbonate 
• 106-39-8 bromochlorobenzene 
• 141-52-6 sodium ethanolate 
• 64-19-7 acetic acid 
• 10026-13-8 phosphorus pentachloride 
• 7791-25-5 sulfuryl dichloride 

Downstream Products

• 105475-33-0 4-(2-ethoxy-5-chloro-phenyl)-4-oxo-butyric acid 
• 101574-09-8 bis-(2-ethoxy-5-chloro-phenyl)-methane 
• 5392-86-9 2,4-dichloro-1-ethoxybenzene 
• 23399-88-4 2,4,6-trichlorophenyl ethyl ether 
• 83802-00-0 1,3,4,5,6-pentachloro-4-ethoxycyclohexene 
• 1147105-68-7 2-(4-ethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 645-26-1 (4-ethoxyphenyl) phenyl sulfide 
• 928709-67-5 C₈H₈Cl₂O₃S 
• 103-73-1 Phenetole 
• 101571-55-5 2,2'-diethoxy-5,5'-dichloro-benzophenone 
• 108904-14-9 2-hydroxy-isophthalic acid mono-(4-chloro-phenyl ester) 
• 6178-89-8 5,5'-dichloro-2,2'-dihydroxybenzophenone 
• 109514-48-9 2-hydroxy-isophthalic acid-(4-chloro-phenyl ester)-methyl ester 
• 156-43-4 4-Ethoxyaniline 

Relevant articles and documents

Mustard Carbonate Analogues as Sustainable Reagents for the Aminoalkylation of Phenols

N,N-dialkyl ethylamine moiety can be found in numerous scaffolds of macromolecules, catalysts, and especially pharmaceuticals. Common synthetic procedures for its incorporation in a substrate relies on the use of a nitrogen mustard gas or on multistep syntheses featuring chlorine hazardous/toxic chemistry. Reported herein is a one-pot synthetic approach for the easy introduction of aminoalkyl chain into different phenolic substrates through dialkyl carbonate (β-aminocarbonate) chemistry. This new direct alcohol substitution avoids the use of chlorine chemistry, and it is efficient on numerous pharmacophore scaffolds with good to quantitative yield. The cytotoxicity via MTT of the β-aminocarbonate, key intermediate of this synthetic approach, was also evaluated and compared with its alcohol precursor.

Electrophotocatalytic SNAr Reactions of Unactivated Aryl Fluorides at Ambient Temperature and Without Base

The electrophotocatalytic SNAr reaction of unactivated aryl fluorides at ambient temperature without strong base is demonstrated.

Practical Ligand-Free Copper-Catalysed Short-Chain Alkoxylation of Unactivated Aryl Bromides

An efficient and practical short-chain alkoxylation of unactivated aryl bromides has been developed with special attention focussed on the applicability of the reaction. Sodium alkoxide is used as the nucleophile, and the corresponding alcohol as the solvent. The reaction requires neither precious metals nor organic ligands. It uses a catalytic system consisting of copper(I) bromide as a catalyst, the corresponding alkyl formate as a noncontaminating cocatalyst, and lithium chloride as an additive. A wide range of substrates and test cases highlight the synthetic utility of the approach. Considering the commercial accessibility and affordability of the feedstocks, this protocol shows promise as a new alternative for the sustainable preparation of aryl alkyl ethers.