62031-54-3

Basic information

• Product Name: FIBROBLAST GROWTH FACTOR, BASIC, HUMAN
• Synonyms: RHFGFB;RHBFGF;RECOMBINANT HUMAN FGF-BASIC;REC FIBROBLAST GROWTH FACTOR BASIC (HUMAN);REC FGF BASIC (HUMAN);NBBFGF;BASIC FIBROBLAST GROWTH FACTOR (FGF 2) HUMAN;BASIC FGF, HUMAN
• CAS NO: 62031-54-3
• Molecular Formula: C62H95N15O15
• Molecular Weight: 1290.51
• Product Categories: Other Peptides;Peptides and Proteins;Peptides for Cell Biology;Peptides;cytokine
• Mol File: 62031-54-3.mol
• Article Data: 0

Chemical Properties

• Appearance: /lyophilized powder
• Storage Temp.: 2-8°C
• Water Solubility: Soluble in water
• CAS DataBase Reference: FIBROBLAST GROWTH FACTOR, BASIC, HUMAN(CAS DataBase Reference)
• NIST Chemistry Reference: FIBROBLAST GROWTH FACTOR, BASIC, HUMAN(62031-54-3)
• EPA Substance Registry System: FIBROBLAST GROWTH FACTOR, BASIC, HUMAN(62031-54-3)

Safety Data

• WGK Germany: 3
• RTECS: LK3641325
• F: 8-10-21-23
• Hazardous Substances Data: 62031-54-3(Hazardous Substances Data)

Usage

Description

Fibroblast Growth Factor, Basic, Human (FGF-2), also known as Basic Fibroblast Growth Factor (BFGF), is a heparin-binding growth factor that is ubiquitously expressed and belongs to the FGF family. It is a single, non-glycosylated polypeptide chain containing 145 amino acids with a molecular weight of 16.3 kDa. FGF-2 plays a crucial role in various cellular processes, including cell proliferation, differentiation, migration, and survival.

Uses

Used in Pharmaceutical Industry:
FGF-2 is used as a therapeutic agent for promoting wound healing, tissue repair, and regeneration. It stimulates the proliferation and migration of various cell types, such as fibroblasts, endothelial cells, and epithelial cells, which aids in the healing process.
Used in Cosmetic Industry:
FGF-2 is used as an active ingredient in cosmetic products for its potential to promote skin regeneration and repair. It can help improve skin texture, reduce the appearance of scars, and stimulate the production of collagen and elastin, contributing to a more youthful and radiant complexion.
Used in Research Applications:
FGF-2 is widely used in research settings as a growth factor to study various cellular processes, such as cell proliferation, differentiation, and migration. It is also used to investigate the underlying mechanisms of tissue repair and regeneration, as well as the role of FGF-2 in various diseases and disorders.
Used in Tissue Engineering and Regenerative Medicine:
FGF-2 is employed in tissue engineering and regenerative medicine as a growth factor to enhance the growth and differentiation of various cell types. It can be incorporated into scaffolds or used in combination with other growth factors to promote tissue repair and regeneration in various applications, such as bone, cartilage, and skin repair.
Used in Neurological Applications:
FGF-2 has been shown to have neuroprotective and neuroregenerative properties, making it a potential therapeutic agent for various neurological disorders, such as stroke, traumatic brain injury, and neurodegenerative diseases. It can promote neuronal survival, axonal growth, and synaptogenesis, contributing to the restoration of neurological function.
Used in Oncology Research:
FGF-2 is involved in various aspects of tumor biology, including angiogenesis, cell proliferation, and invasion. It is used in oncology research to study the role of FGF-2 in tumor growth, metastasis, and resistance to therapy. Understanding the mechanisms of FGF-2 action in cancer may lead to the development of novel therapeutic strategies targeting this growth factor.

Biochem/physiol Actions

FGF-2 (fibroblast growth factor 2, also referred to as BFGF (basic fibroblast growth factor)) stimulates the proliferation of a wide variety of cells including mesenchymal, neuroectodermal and endothelial cells. It is present in the preimplantation embryos and is important for proper development. It is also responsible for angiogenesis. FGF-2 plays a crucial role in adipogenesis and development of adipose tissues. It is associated with tumor growth and metastasis.