62-37-3 Usage
Description
Chlormerodrin, also known as Mercloran and Neohydrin, is a sulfhydryl blocking agent that has been utilized in various applications, particularly in the field of cancer therapy. It is derived from the Parke-Davis and Marion Merrell Dow pharmaceutical companies and has garnered significant attention for its potential in enhancing the effectiveness of cancer treatments.
Uses
Used in Cancer Therapy:
Chlormerodrin is used as a sulfhydryl blocking agent for enhancing the therapeutic efficacy of cancer treatments. It plays a crucial role in the production of induced cellular vesicles (ICVs) using natural killer (NK) cells, especially CAR-modified NK cells. These ICVs are loaded with chemotherapeutic agents, which are then employed in the treatment of cancer. Chlormerodrin's ability to block sulfhydryl groups contributes to the improved delivery and effectiveness of these chemotherapeutic agents, ultimately leading to better outcomes for cancer patients.
Originator
Neohydrin,Lakeside,US,1952
Manufacturing Process
To a refluxing solution of 100 g of allyl urea and 600 ml of absolute methanol
there was added with stirring a suspension of 319 g of mercuric acetate and
600 ml of absolute methanol and 60 ml of glacial acetate acid; complete
solution resulted. After 6 hours of refluxing, the solution was cooled and
clarified by filtration. To this solution there were added 50 g of sodium
chloride and 240 ml of water. After a short time a heavy white precipitate
settled out. This precipitate, which was 3-chloromercuri-2-methoxypropylurea, was filtered, washed and dried.
Therapeutic Function
Diuretic
Check Digit Verification of cas no
The CAS Registry Mumber 62-37-3 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 6 and 2 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 62-37:
(4*6)+(3*2)+(2*3)+(1*7)=43
43 % 10 = 3
So 62-37-3 is a valid CAS Registry Number.
InChI:InChI=1/C5H11N2O2.ClH.Hg/c1-4(9-2)3-7-5(6)8;;/h4H,1,3H2,2H3,(H3,6,7,8);1H;/q;;+1/p-1/rC5H11HgN2O2.ClH/c1-10-4(2-6)3-8-5(7)9;/h4H,2-3H2,1H3,(H3,7,8,9);1H/q+1;/p-1
