61873-93-6

Basic information

• Product Name: Methyl (4-Hydroxy-3-nitrophenyl)acetate
• Synonyms: methyl (4-hydroxy-3-nitrophenyl)acetate;Methyl (4-hydroxy-3-nitrophenyl)acetate 95%;4-(2-Methoxy-2-oxoethyl)-2-nitrophenol;4-(2-Methoxy-2-oxoethyl)-2-nitrophenol, 2-Hydroxy-5-(2-methoxy-2-oxoethyl)nitrobenzene;Methyl(4-hydroxy-3-nitrophenyl)acetate95%;3-Nitro-4-hydroxyphenylacetic acid methyl ester;Methyl 3-nitro-4-hydroxyphenylacetate;4-Hydroxy-3-nitro-phenylacetic acid methl ester
• CAS NO: 61873-93-6
• Molecular Formula: C₉H₉NO₅
• Molecular Weight: 211.17
• Mol File: 61873-93-6.mol
• Article Data: 13

Chemical Properties

• Melting Point: 65-67°
• Boiling Point: 327.6±27.0 °C(Predicted)
• Appearance: /
• Density: 1.384±0.06 g/cm3(Predicted)
• PKA: 6.81±0.14(Predicted)
• CAS DataBase Reference: Methyl (4-Hydroxy-3-nitrophenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl (4-Hydroxy-3-nitrophenyl)acetate(61873-93-6)
• EPA Substance Registry System: Methyl (4-Hydroxy-3-nitrophenyl)acetate(61873-93-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 61873-93-6(Hazardous Substances Data)

Usage

General Description

Methyl (4-Hydroxy-3-nitrophenyl)acetate, also known as p-nitrophenyl methylacetate, is a chemical compound used in various industries, including pharmaceuticals and organic synthesis. It is a colorless to pale yellow liquid with a fruity odor and is soluble in most organic solvents. It is commonly used as a reagent in the synthesis of various organic compounds and as an intermediate in the production of drugs and other fine chemicals. Methyl (4-Hydroxy-3-nitrophenyl)acetate is known for its ability to undergo nucleophilic substitution reactions and is a versatile intermediate with a wide range of applications in the chemical and pharmaceutical industries.

Upstream product

• 67-56-1 methanol 
• 10463-20-4 4-hydroxy-3-nitrophenylacetic acid 
• 104-01-8 4-Methoxyphenylacetic acid 
• 34837-88-2 methyl 2-(4-methoxy-3-nitrophenyl)acetate 
• 23786-14-3 4-methoxy-phenyl acetic acid methyl ester 
• 156-38-7 4-hydroxyphenylacetate 
• 14199-15-6 Methyl 4-hydroxyphenylacetate 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 186581-53-3 diazomethane 

Downstream Products

• 59346-85-9 methyl 3-nitro-4-propargyloxyphenylacetate 
• 59346-84-8 methyl 3-nitro-4-allyloxyphenylacetate 
• 59346-86-0 methyl 3-nitro-4-methallyloxyphenylacetate 
• 1422169-72-9 methyl 2-(3-(3,5-dimethylisoxazole-4-carboxamido)-4-hydroxyphenyl)acetate 
• 34837-88-2 methyl 2-(4-methoxy-3-nitrophenyl)acetate 
• 134997-91-4 2-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)acetic acid 
• 866038-49-5 methyl 2-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)acetate 
• 1455471-90-5 ethyl 2-(4-(2-methoxy-2-oxoethyl)-2-nitrophenoxy)acetate 

Relevant articles and documents

SECONDARY METABOLITES OF Pyricularia oryzae. I. o-NITROPHENOL DERIVATIVES

o-Nitrophenol derivatives have been isolated from the culture liquid of the deuteromycete Pyricularia oryzae Cav.: 4-hydroxy-3-nitrophenylacetic acid, 4-hydroxy-3-nitrobenzyl alcohol, 1- and 2-(4-hydroxy-3-nitrophenyl)ethanols, N-(4-hydroxy-3-nitrophenylethyl)acetamide, and pyriculamide.This is the first time that any of these compounds has been isolated from natural sources.The o-nitrophenols obtained possess moderate growth-inhibiting activity in relation to rice shoots.

COMPOUNDS AND METHODS

The present invention relates to novel retinoid-related orphan receptor gamma (RORγ) modulators and their use in the treatment of diseases mediated by RORy.

Synthetic route to a benzooxazole derivative with heparanase inhibitory activity

The synthesis of a benzooxazol-5-yl acetic acid derivative (9) with strong heparanase and angiogenesis inhibitory activity, and thus possible commercial interest, is described in detail. Copyright Taylor & Francis Group, LLC.